Comprehensive study of co-processed excipients F- Melts (R): Flow, viscoelastic and compacts properties

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16370%2F19%3A43877718" target="_blank" >RIV/62157124:16370/19:43877718 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11160/19:10400134

Result on the web

<a href="https://www.sciencedirect.com/science/article/pii/S0032591019305406" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0032591019305406</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.powtec.2019.07.048" target="_blank" >10.1016/j.powtec.2019.07.048</a>

Result language

angličtina

Original language name

Comprehensive study of co-processed excipients F- Melts (R): Flow, viscoelastic and compacts properties

Original language description

This article aims to compare three commercially available co-processed excipients (CPEs), namely the F-Melts (R) type C, M and F1. All three CPEs were subjected to the evaluation of their physical properties and afterwards compacts were prepared using three compression pressures. The viscoelastic properties and ejection force were assayed during the compression and the compacts were evaluated in compliance with the European Pharmacopoeia and subjected to other relevant testing (AFM imaging, wettability etc.). Based on the obtained results it could be stated that the C and M have very similar properties according to their similar composition. In general, it is difficult to select the best CPE as they possess different properties fitting the versatile needs of manufacturers. However, the obtained results revealed that the M and F1 are more suitable for the incorporation of moisture-sensitive ingredients than the C. (C) 2019 Elsevier B.V. All rights reserved.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30104 - Pharmacology and pharmacy

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2019

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Powder technology

ISSN

0032-5910

e-ISSN

—

Volume of the periodical

355

Issue of the periodical within the volume

October

Country of publishing house

NL - THE KINGDOM OF THE NETHERLANDS

Number of pages

13

Pages from-to

675-687

UT code for WoS article

000499760600068

EID of the result in the Scopus database

2-s2.0-85073643332