Comparison of Flow and Compression Properties of Four Lactose-Based Co-Processed Excipients: Cellactose (R) 80, CombiLac (R), MicroceLac (R) 100, and StarLac (R)

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11160%2F21%3A10434425" target="_blank" >RIV/00216208:11160/21:10434425 - isvavai.cz</a>

Alternative codes found

RIV/61989592:15310/21:73610447 RIV/00216224:14160/21:00122737

Result on the web

<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=7qzMM5TeQt" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=7qzMM5TeQt</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3390/pharmaceutics13091486" target="_blank" >10.3390/pharmaceutics13091486</a>

Result language

angličtina

Original language name

Comparison of Flow and Compression Properties of Four Lactose-Based Co-Processed Excipients: Cellactose (R) 80, CombiLac (R), MicroceLac (R) 100, and StarLac (R)

Original language description

The utilization of co-processed excipients (CPEs) represents a novel approach to the preparation of orally disintegrating tablets by direct compression. Flow, consolidation, and compression properties of four lactose-based CPEs-Cellactose (R) 80, CombiLac (R), MicroceLac (R) 100, and StarLac (R)-were investigated using different methods, including granulometry, powder rheometry, and tablet compaction under three pressures. Due to the similar composition and the same preparation technique (spray drying), the properties of CPEs and their compacts were generally comparable. The most pronounced differences were observed in flowability, undissolved fraction after 3 min and 24 h, energy of plastic deformation (E-2), ejection force, consolidation behavior, and compact friability. Cellactose (R) 80 exhibited the most pronounced consolidation behavior, the lowest values of ejection force, and high friability of compacts. CombiLac (R) showed excellent flow properties but insufficient friability, except for compacts prepared at the highest compression pressure (182 MPa). MicroceLac (R) 100 displayed the poorest flow properties, lower ejection forces, and the best mechanical resistance of compacts. StarLac (R) showed excellent flow properties, the lowest amounts of undissolved fraction, the highest ejection force values, and the worst compact mechanical resistance. The obtained results revealed that higher compression pressures need to be used or further excipients have to be added to all tested materials in order to improve the friability and tensile strength of formed tablets, except for MicroceLac (R) 100.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30104 - Pharmacology and pharmacy

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2021

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Pharmaceutics

ISSN

1999-4923

e-ISSN

—

Volume of the periodical

13

Issue of the periodical within the volume

9

Country of publishing house

CH - SWITZERLAND

Number of pages

21

Pages from-to

1486

UT code for WoS article

000701444400001

EID of the result in the Scopus database

2-s2.0-85116163555