Study of rheological and tableting properties of lubricated mixtures of co-processed dry binders for orally disintegrating tablets
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62690094%3A18470%2F22%3A50018499" target="_blank" >RIV/62690094:18470/22:50018499 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11160/22:10450135
Result on the web
<a href="https://www.sciencedirect.com/science/article/pii/S0928098721003389" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0928098721003389</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.ejps.2021.106035" target="_blank" >10.1016/j.ejps.2021.106035</a>
Alternative languages
Result language
angličtina
Original language name
Study of rheological and tableting properties of lubricated mixtures of co-processed dry binders for orally disintegrating tablets
Original language description
Co-processed dry binders for ODTs are important multifunctional excipients for tablet manufacturing by direct compression. Testing their binary mixtures with lubricants is an important aspect of their use in combination with drugs. The aim of this study was to evaluate the rheological and compression properties of lubricated mixtures of co-processed dry binders Parteck (R) ODT, Prosolv (R) ODT G2 and Ludiflash (R), and subsequently also the compactability and disintegration time of the tablets made thereof. The lubricants employed were magnesium stearate and sodium stearyl fumarate in the concentrations of 0.5% and 1%. The best flowability was shown by Prosolv (R) ODT G2 combined with magnesium stearate in the concentration of 0.5%. Lubricated mixtures with Prosolv (R) ODT G2 showed a lower angle of internal friction as well as lower pre-compression energy values. The values of plastic deformation energy were the highest in the case of Prosolv (R) ODT G2, which was also reflected in the highest tablet strength. On the contrary, the ejection force values were the lowest for this co-processed dry binder. Magnesium stearate reduced the ejection force more effectively than sodium stearyl fumarate. Prosolv (R) ODT G2 tablets exhibited the highest tensile strength and shortest disintegration time.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10403 - Physical chemistry
Result continuities
Project
—
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2022
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
European journal of pharmaceutical sciences
ISSN
0928-0987
e-ISSN
1879-0720
Volume of the periodical
168
Issue of the periodical within the volume
leden
Country of publishing house
NL - THE KINGDOM OF THE NETHERLANDS
Number of pages
10
Pages from-to
"Article Number: 106035"
UT code for WoS article
000708663100006
EID of the result in the Scopus database
2-s2.0-85117198881