Improvement of Glibenclamide Water Solubility by Nanoparticle Preparation

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16370%2F19%3A43878258" target="_blank" >RIV/62157124:16370/19:43878258 - isvavai.cz</a>
Alternative codes found
RIV/61989100:27640/19:10238407 RIV/61989100:27740/19:10238407
Result on the web
<a href="https://doi.org/10.1166/jnn.2019.15876" target="_blank" >https://doi.org/10.1166/jnn.2019.15876</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1166/jnn.2019.15876" target="_blank" >10.1166/jnn.2019.15876</a>

Result language
angličtina
Original language name
Improvement of Glibenclamide Water Solubility by Nanoparticle Preparation
Original language description
Glibenclamide, a drug used for the treatment of type 2 diabetes, belongs to Class II of Biopharmaceutical Classification System. It is a highly permeable, but poorly water-soluble drug. Nanoparticles of glibenclamide were prepared by an emulsion solvent evaporation method using dichloromethane as a solvent of glibenclamide and 3% (w/w) aqueous solution of carboxymethyl dextran sodium salt as a stabilizer, which was found as optimal. A solubility test comparing the water solubility of glibenclamide bulk and nanoparticles confirmed the improved (2-fold higher) solubility of glibenclamide nanoparticles (0.045 mu g/ml) compared with bulk (0.024 mu g/ml).
Czech name
—
Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
30107 - Medicinal chemistry

Project
<a href="/en/project/LQ1602" target="_blank" >LQ1602: IT4Innovations excellence in science</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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