Regulatory motifs in p53 biology - G-quadruplexes

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16370%2F19%3A43878278" target="_blank" >RIV/62157124:16370/19:43878278 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Regulatory motifs in p53 biology - G-quadruplexes
Original language description
The focus of our work is the structure-specific binding of wild-type p53 and mutant p53 to DNA containing quadruplex-forming sequences in vitro and in cells and the effect on p53-driven transcription. CD analysis indicated that mutant p53 not only binds to G-quadruplex DNA, but also stabilizes G-quadruplex folds. Finally, we found that mutant p53 R273H preferentially binds to G/C-rich DNA around transcription start sites of many genes characterized by active chromatin marks and frequently associated with transcription-competent RNA polymerase II. We propose the role of G-quadruplexes as non-B DNA recognition motifs of wild-type and mutant p53 protein for transcriptional regulation of selected p53 target genes.
Czech name
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Czech description
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Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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