DEOXYNIVALENOL: METABOLISM AND REGIONAL DIFFERENCES IN HUMAN EXPOSURE
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62690094%3A18450%2F14%3A50002641" target="_blank" >RIV/62690094:18450/14:50002641 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
DEOXYNIVALENOL: METABOLISM AND REGIONAL DIFFERENCES IN HUMAN EXPOSURE
Original language description
Deoxynivalenol (DON) is one of the most abundant mycotoxins in contaminated food and feed worldwide. It is toxic to humans and inhibits DNA, RNA and protein synthesis. In this review, the metabolism of DON and its exposure in humans from different regions are summarized. Conjugated products DON-3-glucuronide, DON-15-glucuronide, and DON-7-glucuronide are found to be the major metabolites in humans. Human exposure of DON shows some regional differences due to the different DON levels in cereal-based foods and the food intake habits. C12,13-deepoxy metabolite, DOM-1 can be found in most French populations but is rarely detected in UK adults. Spanish exposes lower DON levels than the UK populations. A very high DON exposure is detected in South Africa andLinxian, China. Fetus is shown to expose to DON during pregnancy in human. This review will provide global information of DON metabolism and exposure in humans and facilitate the mycotoxin control strategies.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
KA - Militarism
OECD FORD branch
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Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Vojenské zdravotnické listy=Military medical science letters
ISSN
0372-7025
e-ISSN
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Volume of the periodical
83
Issue of the periodical within the volume
3
Country of publishing house
CZ - CZECH REPUBLIC
Number of pages
6
Pages from-to
114-119
UT code for WoS article
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EID of the result in the Scopus database
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