Gender and geographical variability in the exposure pattern and metabolism of deoxynivalenol in humans: a review.

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62690094%3A18450%2F17%3A50005074" target="_blank" >RIV/62690094:18450/17:50005074 - isvavai.cz</a>

Alternative codes found

RIV/00179906:_____/17:10331716

Result on the web

<a href="http://dx.doi.org/10.1002/jat.3359" target="_blank" >http://dx.doi.org/10.1002/jat.3359</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1002/jat.3359" target="_blank" >10.1002/jat.3359</a>

Result language

angličtina

Original language name

Gender and geographical variability in the exposure pattern and metabolism of deoxynivalenol in humans: a review.

Original language description

Deoxynivalenol (DON, also known as vomitoxin) is a common mycotoxin found worldwide, especially in contaminated food. DON is toxic to a variety of cells and tissues in humans. Three kinds of conjugated products (DON-3-glucuronide, DON-15-glucuronide and DON-7-glucuronide) can be found as major metabolites in human urine. Females and males show different patterns of exposure levels, and human exposure to DON also shows some geographical differences because of different DON levels in cereal-based foods, food intake habits and UDP-glucuronosyltransferase expression. Specifically, the C12, 13-deepoxymetabolite was found predominantly in French adults but was rarely detected in UK adults. However, a cohort of Spanish individuals demonstrated even lower DON levels than the levels in the UK populations, whereas a very high DON exposure level was detected in South Africa and Linxian, China. Recent publications have further indicated that DON could be detected in the urine of pregnant women from different countries, which suggests that there is a potential risk to both mothers and foetuses. Additionally, phytochemicals have been shown to be less toxic to cells and laboratory animals in research studies and may also be used as food additives for reducing the toxic effects of DON. In this review, we provide global information on DON metabolism, human exposure and gender differences in humans. Also, control strategies for this mycotoxin are discussed

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30108 - Toxicology

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2017

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Journal of applied toxicology

ISSN

0260-437X

e-ISSN

—

Volume of the periodical

37

Issue of the periodical within the volume

1

Country of publishing house

US - UNITED STATES

Number of pages

11

Pages from-to

60-70

UT code for WoS article

000388295300006

EID of the result in the Scopus database

2-s2.0-84989216685