Deoxynivalenol: Emerging Toxic Mechanisms and Control Strategies, Current and Future Perspectives
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62690094%3A18470%2F23%3A50020546" target="_blank" >RIV/62690094:18470/23:50020546 - isvavai.cz</a>
Result on the web
<a href="https://pubs.acs.org/doi/10.1021/acs.jafc.3c02020" target="_blank" >https://pubs.acs.org/doi/10.1021/acs.jafc.3c02020</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1021/acs.jafc.3c02020" target="_blank" >10.1021/acs.jafc.3c02020</a>
Alternative languages
Result language
angličtina
Original language name
Deoxynivalenol: Emerging Toxic Mechanisms and Control Strategies, Current and Future Perspectives
Original language description
Deoxynivalenol (DON) is the most frequently present mycotoxin contaminant in food and feed, causing a variety of toxic effects in humans and animals. Currently, a series of mechanisms involved in DON toxicity have been identified. In addition to the activation of oxidative stress and the MAPK signaling pathway, DON can activate hypoxia-inducible factor-1 alpha, which further regulates reactive oxygen species production and cancer cell apoptosis. Noncoding RNA and signaling pathways including Wnt/beta-catenin, FOXO, and TLR4/NF-kappa B also participate in DON toxicity. The intestinal microbiota and the brain-gut axis play a crucial role in DON-induced growth inhibition. In view of the synergistic toxic effect of DON and other mycotoxins, strategies to detect DON and control it biologically and the development of enzymes for the biodegradation of various mycotoxins and their introduction in the market are the current and future research hotspots.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30108 - Toxicology
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2023
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
ISSN
0021-8561
e-ISSN
1520-5118
Volume of the periodical
71
Issue of the periodical within the volume
29
Country of publishing house
US - UNITED STATES
Number of pages
15
Pages from-to
10901-10915
UT code for WoS article
001029054000001
EID of the result in the Scopus database
2-s2.0-85165619753