Deoxynivalenol: signaling pathways and human exposure risk assessment-an update

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00179906%3A_____%2F14%3A10282617" target="_blank" >RIV/00179906:_____/14:10282617 - isvavai.cz</a>

Alternative codes found

RIV/62690094:18450/14:50002606 RIV/62690094:18470/14:50002606

Result on the web

<a href="http://link.springer.com/article/10.1007%2Fs00204-014-1354-z" target="_blank" >http://link.springer.com/article/10.1007%2Fs00204-014-1354-z</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s00204-014-1354-z" target="_blank" >10.1007/s00204-014-1354-z</a>

Result language

angličtina

Original language name

Deoxynivalenol: signaling pathways and human exposure risk assessment-an update

Original language description

Deoxynivalenol (DON) is a group B trichothecene and a common contaminant of crops worldwide. This toxin is known to cause a spectrum of diseases in animals and humans such as vomiting and gastroenteritis. Importantly, DON could inhibit the synthesis of protein and nucleonic acid and induce cell apoptosis in eukaryote cells. The transduction of signaling pathways is involved in the underlying mechanism of the cytotoxicity of DON. Mitogen-activated protein kinase and Janus kinase/signal transducer and activator of transcription seem to be two important signaling pathways and induce the inflammatory response by modulating the binding activates of specific transcription factors. This review mainly discussed the toxic mechanism of DON from the vantage pointof signaling pathways and also assessed the profiles of DON and its metabolites in humans. Importantly, we conducted a human exposure risk assessment of DON from cereals, cereal-based foods, vegetables, water, and animal-derived foods in

Czech name

—

Czech description

—

Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FP - Other medical fields

OECD FORD branch

—

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2014

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Archives of Toxicology

ISSN

0340-5761

e-ISSN

—

Volume of the periodical

88

Issue of the periodical within the volume

11

Country of publishing house

DE - GERMANY

Number of pages

14

Pages from-to

1915-1928

UT code for WoS article

000344070300003

EID of the result in the Scopus database

—