Pyrrolidine Dithiocarbamate (PDTC) Inhibits DON-Induced Mitochondrial Dysfunction and Apoptosis via the NF-kappa B/iNOS Pathway

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62690094%3A18470%2F18%3A50015453" target="_blank" >RIV/62690094:18470/18:50015453 - isvavai.cz</a>

Result on the web

<a href="https://www.hindawi.com/journals/omcl/2018/1324173/" target="_blank" >https://www.hindawi.com/journals/omcl/2018/1324173/</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1155/2018/1324173" target="_blank" >10.1155/2018/1324173</a>

Result language

angličtina

Original language name

Pyrrolidine Dithiocarbamate (PDTC) Inhibits DON-Induced Mitochondrial Dysfunction and Apoptosis via the NF-kappa B/iNOS Pathway

Original language description

Oxidative stress is closely linked to the toxic responses of various cell types in normal and pathophysiological conditions. Deoxynivalenol (DON), an inducer of stress responses in the ribosome and the endoplasmic reticulum (ER), causes mitochondrial dysfunction and mitochondria-dependent apoptosis through oxidative stress in humans and animals. The NF-kappa B pathway, which is closely linked to oxidative stress, is hypothesized to be a critical signaling pathway for DON-induced toxicity and is a potential target for intervention. The present study was conducted to explore the protective effects of pyrrolidine dithiocarbamate (PDTC) from the toxic effects of DON in rat anterior pituitary GH3 cells. Our results showed that DON activated the NF-kappa B transcription factors and induced cellular oxidative stress, mitochondrial dysfunction, and apoptosis. Morphological studies using transmission electron microscopy (TEM) and cell apoptosis analyses suggested that PDTC prevented DON-induced mitochondrial dysfunction and apoptosis, probably by preventing the DON-induced translocation of NF-kappa B p65 into the nucleus, and by inhibiting DON-induced iNOS expression. This led to the blocking of the NF-kappa B pathway and inhibition of iNOS activity.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30107 - Medicinal chemistry

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2018

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Oxidative medicine and cellular longevity

ISSN

1942-0900

e-ISSN

—

Volume of the periodical

Neuveden

Issue of the periodical within the volume

November

Country of publishing house

GB - UNITED KINGDOM

Number of pages

8

Pages from-to

1-8

UT code for WoS article

000452990200001

EID of the result in the Scopus database

2-s2.0-85059288468