Kinetic parameters survey for manufacture of pralidoxime

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62690094%3A18450%2F15%3A50003725" target="_blank" >RIV/62690094:18450/15:50003725 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.11648/j.ajche.20150303.12" target="_blank" >http://dx.doi.org/10.11648/j.ajche.20150303.12</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.11648/j.ajche.20150303.12" target="_blank" >10.11648/j.ajche.20150303.12</a>

Result language
angličtina
Original language name
Kinetic parameters survey for manufacture of pralidoxime
Original language description
Chemical agents represent a serious threat to the modern world. Among them, they stand out nerve agents because of its high lethality and dangerousness. They are typically organophosphate compounds, which act by inhibiting acetylcholinesterase, a key enzyme in the transmission of nerve impulses process. There are several forms of treatment for organophosphate poisoning, and pralidoxime (2-PAM) is the drug most used as reactivator of acetylcholinesterase. In this work, we developed the first three stepsfor the synthesis of 2-PAM, with the objective of obtaining data to calculate the kinetic parameters of these steps. These parameters may be used for the manufacture of 2-PAM in semi-pilot scale. Through the studies conducted it has been found that the preparation of the oxime has very rapid kinetics.
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CI - Industrial chemistry and chemical engineering
OECD FORD branch
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Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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