Synthesis of the three monopyridinium oximes and evaluation of their potency to reactivate acetylcholinesterase inhibited by nerve agents

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60162694%3AG38__%2F04%3A00001081" target="_blank" >RIV/60162694:G38__/04:00001081 - isvavai.cz</a>

Alternative codes found

RIV/60461373:22310/04:00020154

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Synthesis of the three monopyridinium oximes and evaluation of their potency to reactivate acetylcholinesterase inhibited by nerve agents

Original language description

Three potential reactivators of nerve agents-inhibited acetylcholinesterase: 2-[(hydroxyimino)phenylmethyl]-1-methylpyridinium iodide 3a, 2-[(hydroxyimino)pyridin-2-ylmethyl]-1-methylpyridinium iodide 3b and 2-[(1-hydroxyimino) ethyl]-1-methylpyridiniumiodide 3c were synthesized. Their reactivation potency was examined using standard in vitro reactivation test. A rat brain homogenate was used as the source of acetylcholinesterase. Their reactivation potency was compared with currently used acetylcholinesterase reactivator - 2-PAM (pralidoxime) 4. All tested reactivators were less effective acetylcholinesterase reactivators compared to 2-PAM. In this paper, we have also tested reactivation potency of the oxime 2-PAM against inhibition of acetylcholinesterase by sarin, cyclosarin, VX and tabun. Satisfactory results are only shown for the reactivation sarin- and VX-inhibited acetylcholinesterase.

Czech name

Syntéza třech monopyridiniových oximů a zhodnocení jejich účinnosti při reaktivaci acetylcholinesterazy inhibované nervově paralytickými látkami

Czech description

Syntéza třech monopyridiniových oximů a zhodnocení jejich účinnosti při reaktivaci acetylcholinesterazy inhibované nervově paralytickými látkami

Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FP - Other medical fields

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2004

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Journal of Applied Biomedicine

ISSN

1214-021X

e-ISSN

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Volume of the periodical

2

Issue of the periodical within the volume

1

Country of publishing house

CZ - CZECH REPUBLIC

Number of pages

6

Pages from-to

51-56

UT code for WoS article

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EID of the result in the Scopus database

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