New group of monoquaternary reactivators of the acetylcholinesterase inhibited by nerve agents
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60162694%3AG44__%2F05%3A00001349" target="_blank" >RIV/60162694:G44__/05:00001349 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
New group of monoquaternary reactivators of the acetylcholinesterase inhibited by nerve agents
Original language description
Reactivators of acetylcholinesterase (AChE; EC 3.1.1.7) are compounds, which are able to treat intoxication with organophosphorus compounds, especially with pesticides or nerve agents. Owing to the fact that there exist no universal "broad-spectrum" reactivator of oranophosphates-inhibited AChE, many laboratories from the world synthesize new AChE reactivators. In our work, there were synthesized five new and three already known quaternary monopyridinium oximes as potential reactivators of AChE inhibited by nerve agents. Potencies to cleave p-nitrophenyl acetate (PNPA), which is commonly used as model substrate of the nerve agents, were measured. Their cleaving potencies were compared with 4-PAM (4-hydroxyiminomethyl-1-methylpyridinium iodide), which is derived from the structure of the currently used AChE-reactivator 2-PAM (2-hydroxyiminomethyl-1-methylpyridinium iodide). Three newly synthesized oximes achieved similar nuclephilicity at the similar pKa according to 4-PAM, what is very
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FP - Other medical fields
OECD FORD branch
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Result continuities
Project
<a href="/en/project/ONVLAJEP20031" target="_blank" >ONVLAJEP20031: New possibilities of therapy of cyclosin intoxication: Synthesis and testing of new acethylcholinesterase reactivators</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2005
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of Enzyme Inhibition and Medicinal Chemistry
ISSN
1475-6366
e-ISSN
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Volume of the periodical
20
Issue of the periodical within the volume
3
Country of publishing house
GB - UNITED KINGDOM
Number of pages
5
Pages from-to
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UT code for WoS article
000230820000004
EID of the result in the Scopus database
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