Substituted monoquaternary oximes as reactivators of cyclosarin and chlorpyrifos inhibited acetylcholinesterase
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60162694%3AG44__%2F06%3A00001591" target="_blank" >RIV/60162694:G44__/06:00001591 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Substituted monoquaternary oximes as reactivators of cyclosarin and chlorpyrifos inhibited acetylcholinesterase
Original language description
This paper describes an in vitro study of three potential acetylcholinesterase AChE; EC 3.1.1.7) reactivatorsderived from a monoquaternary reactivator pralidoxime. Compounds used were pyridinium-2-aldoxime-4-carbamoyl-N-methyl iodide (TO231), pyridinium-2-aldoxime-4-ethoxycarbonyl-N-methyl iodide (TO237),and pyridinium-2-aldoxime-5-ethoxycarbonyl-N-methyl iodide (TO238). Pralidoxime and obidoxime wereused for comparison. Nerve agent cyclosarin and pesticide chlorpyrifos were used as organophosphoruscholinesterase inhibitors. The source of AChE was rat brain homogenate. None of the tested oximes was able to reactivate cyclosarin-inhibited AChE (at 1.0 mmol L-1 oxime concentration). In case of chlorpyrifos, TO231 was the most potent AChE reactivator withan 82 % reactivation at 1.0 mmol L-1 oxime concentration. Thisreactivating potency equals that of pralidoxime and obidoxime. TO238 was less effective, and TO237 did not reactivate chlorpyrifos-inhibited AChE at all. None of the tested AC
Czech name
Substituované monokvarterní oximy jako reaktivátory cyklosarinem a chlorpyrifosem inhibované acetylcholinesterázy
Czech description
V rámci této práce byly testovány monokavarterní pyridiniové aldoximy modifikované na pyridiniovém jádru druhým substituentem. Následně byla testována jejich schopnost reaktivovat AChE inhibovanou cyklosarinem a chlorpyrifosem.
Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FP - Other medical fields
OECD FORD branch
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Result continuities
Project
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Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)
Others
Publication year
2006
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Archives of Industrial Hygiene and Toxicology
ISSN
0004-1254
e-ISSN
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Volume of the periodical
57
Issue of the periodical within the volume
4
Country of publishing house
HR - CROATIA
Number of pages
4
Pages from-to
387-390
UT code for WoS article
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EID of the result in the Scopus database
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