Fipronil insecticide toxicology: oxidative stress and metabolism
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62690094%3A18450%2F16%3A50005075" target="_blank" >RIV/62690094:18450/16:50005075 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1080/10408444.2016.1223014" target="_blank" >http://dx.doi.org/10.1080/10408444.2016.1223014</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1080/10408444.2016.1223014" target="_blank" >10.1080/10408444.2016.1223014</a>
Alternative languages
Result language
angličtina
Original language name
Fipronil insecticide toxicology: oxidative stress and metabolism
Original language description
Fipronil (FIP) is widely used across the world as a broad-spectrum phenylpyrazole insecticide and veterinary drug. FIP was the insecticide to act by targeting the c-aminobutyric acid (GABA) receptor and has favorable selective toxicity towards insects rather than mammals. However, because of accidental exposure, incorrect use of FIP or widespread FIP use leading to the contamination of water and soil, there is increasing evidence that FIP could cause a variety of toxic effects on animals and humans, such as neurotoxic, hepatotoxic, nephrotoxic, reproductive, and cytotoxic effects on vertebrate and invertebrates. In the last decade, oxidative stress has been suggested to be involved in the various toxicities induced by FIP. To date, few reviews have addressed the toxicity of FIP in relation to oxidative stress. The focus of this article is primarily intended to summarize the progress in research associated with oxidative stress as a possible mechanism for FIP-induced toxicity as well as etabolism. The present review reports that studies have been conducted to reveal the generation of reactive oxygen species (ROS) and oxidative stress as a result of FIP treatment and have correlated them with various types of toxicity. Furthermore, the metabolism of FIP was also reviewed, and during this process, various CYP450 enzymes were involved and oxidative stress might occur. The roles of various compounds in protecting against FIP-induced toxicity based on their anti-oxidative effects were also summarized to further understand the role of oxidative stress in FIP-induced toxicity.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FP - Other medical fields
OECD FORD branch
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Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2016
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Critical reviews in toxicology
ISSN
1040-8444
e-ISSN
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Volume of the periodical
46
Issue of the periodical within the volume
10
Country of publishing house
US - UNITED STATES
Number of pages
24
Pages from-to
876-899
UT code for WoS article
000388726200003
EID of the result in the Scopus database
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