Mechanism of Neonicotinoid Toxicity: Impact on Oxidative Stress and Metabolism

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62690094%3A18450%2F18%3A50014312" target="_blank" >RIV/62690094:18450/18:50014312 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.1146/annurev-pharmtox-010617-052429" target="_blank" >http://dx.doi.org/10.1146/annurev-pharmtox-010617-052429</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1146/annurev-pharmtox-010617-052429" target="_blank" >10.1146/annurev-pharmtox-010617-052429</a>

Result language

angličtina

Original language name

Mechanism of Neonicotinoid Toxicity: Impact on Oxidative Stress and Metabolism

Original language description

Thousands of tons of neonicotinoids are widely used around the world as broad-spectrum systemic insecticides and veterinary drugs. Researchers originally thought that neonicotinoids exhibited low mammalian toxicity. However, following their widespread use, it became increasingly evident that neonicotinoids could have various toxic effects on vertebrates and invertebrates. The primary focus of this review is to summarize the research progress associated with oxidative stress as a plausible mechanism for neonicotinoid-induced toxicity as well as neonicotinoid metabolism. This review summarizes the research conducted over the past decade into the production of reactive oxygen species, reactive nitrogen species, and oxidative stress as a result of neonicotinoid treatments, along with their correlation with the toxicity and metabolism of neonicotinoids. The metabolism of neonicotinoids and protection of various compounds against neonicotinoid-induced toxicity based on their antioxidative effects is also discussed. This review sheds new light on the critical roles of oxidative stress in neonicotinoid-induced toxicity to nontarget species.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30104 - Pharmacology and pharmacy

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2018

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Annual review of pharmacology and toxicology

ISSN

0362-1642

e-ISSN

—

Volume of the periodical

58

Issue of the periodical within the volume

January

Country of publishing house

US - UNITED STATES

Number of pages

37

Pages from-to

471-507

UT code for WoS article

000424635500024

EID of the result in the Scopus database

2-s2.0-85040581167