Study on Medicinal Chemistry of K203 in Wistar Rats and Beagle Dogs
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62690094%3A18470%2F13%3A50001680" target="_blank" >RIV/62690094:18470/13:50001680 - isvavai.cz</a>
Result on the web
<a href="http://www.benthamscience.com/contents.php?in=108957&m=May&y=2013" target="_blank" >http://www.benthamscience.com/contents.php?in=108957&m=May&y=2013</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.2174/0929867311320160006" target="_blank" >10.2174/0929867311320160006</a>
Alternative languages
Result language
angličtina
Original language name
Study on Medicinal Chemistry of K203 in Wistar Rats and Beagle Dogs
Original language description
K203 is an experimental bis-pyridinium mono-aldoxime type cholinesterase reactivator of potential use in organophosphate/organophosphonate poisoning. Pharmacokinetics of K203 were examined in Wistar rats and beagle dogs using ion-pair HPLC. Serum and cerebrospinal fluid concentrations of K203 were determined using ion-pair reversed-phase chromatography on octadecyl silica column. HPLC with ultraviolet detection was used for determination of serum concentration of K203 higher than 0.1 mu g/mL while its low concentrations in cerebrospinal fluid required electrochemical detection (0.015 through 4 mu g/mL range). In rats the serum levels of K203 followed zero order pharmacokinetics from 15 to 120 minutes post administration. Zero order pharmacokinetics wasalso observed in beagle dogs after low dose (15 mu mol/kg) of K203 administration. High dose administration (250 mu mol/kg) led to subsequent hindered elimination from both cerebrospinal fluid and serum.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FR - Pharmacology and apothecary chemistry
OECD FORD branch
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Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Current medicinal chemistry
ISSN
0929-8673
e-ISSN
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Volume of the periodical
20
Issue of the periodical within the volume
16
Country of publishing house
US - UNITED STATES
Number of pages
8
Pages from-to
2137-2144
UT code for WoS article
000317662200006
EID of the result in the Scopus database
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