Dose?response efficacy and long-term effect of the hypocholesterolemic effect of octadecylpectinamide in rats

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00027014%3A_____%2F13%3A%230001857" target="_blank" >RIV/00027014:_____/13:#0001857 - isvavai.cz</a>
Result on the web
<a href="http://www.vuzv.cz/sites/File/_privat/13088.pdf" target="_blank" >http://www.vuzv.cz/sites/File/_privat/13088.pdf</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.carbpol.2013.05.044" target="_blank" >10.1016/j.carbpol.2013.05.044</a>

Result language
angličtina
Original language name
Dose?response efficacy and long-term effect of the hypocholesterolemic effect of octadecylpectinamide in rats
Original language description
The dose?response efficiency and long-term effect of the hypocholesterolemic effect of octadecylpectinamide was examined in female rats fed diets containing cholesterol at 10 g/kg. In our first experiment, amidated pectin supplied at 20 g/kg, 40 g/kg and60 g/kg significantly decreased serum cholesterol from 3,32 mol/ml (control) to 1,23 mol/ml in a dose-dependent manner. In a second experiment, the hypocholesterolemic effect of amidated pectin supplied at 20 g/kg persisted after 3 months of feeding. Inboth experiments, the amidated pectin significantly decreased the concentrations of cholesterol in hepatic tissue and triacylglycerols in serum. The serum concentration of aspartate aminotransferase significantly increased in rats fed amidated pectin at60 g/kg for 4 weeks, and at 20 g/kg for 3 months. In onclusion, amidated pectin at a low dose and used for a period shorter than 3 months might be considered as an effective hypocholesterolemic and lipid-lowering agent that may substitut
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
GH - Nutrition of farm animals
OECD FORD branch
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Project
<a href="/en/project/GAP503%2F11%2F2479" target="_blank" >GAP503/11/2479: Inhibition of intestinal absorption of sterols by hydrophobically modified polysaccharides</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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