Free Radicals and Antioxidants in Human Disease

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62690094%3A18470%2F17%3A50016139" target="_blank" >RIV/62690094:18470/17:50016139 - isvavai.cz</a>
Result on the web
<a href="https://www.springer.com/gp/book/9783319676234" target="_blank" >https://www.springer.com/gp/book/9783319676234</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/978-3-319-67625-8_12" target="_blank" >10.1007/978-3-319-67625-8_12</a>

Result language
angličtina
Original language name
Free Radicals and Antioxidants in Human Disease
Original language description
Free radicals are species containing one or more unpaired electrons. Unpaired or free electrons are responsible for enhanced reactivity of free radicals with various biomolecules. Most frequently occurring radicals in biological systems are reactive oxygen species (ROS) and reactive nitrogen species (RNS). ROS and RNS are generated by the tightly regulated enzymes, nicotinamide adenine dinucleotide phosphate oxidase isoforms and nitric oxide synthases. Overproduction of ROS and RNS results in oxidative and nitrosative stress, a state which is responsible for the damage to cell macromolecules including lipids, proteins and DNA. Oxidative stress has been implicated in the aetiology of various disease states of an organism. In this chapter, we discuss the biochemistry of free radicals and their impact on the development of various diseases. Organs of biological systems are the principal targets of oxidant species, which are implicated in atherosclerosis, diabetes, carcinogenesis and neurodegeneration. Attention is focused on oxidative stress-induced cardiovascular disease, type 2 diabetes, cancer and Alzheimer’s disease. The roles of redox active metal-catalysed formation of ROS and antioxidants in protection against oxidative damage is also discussed.
Czech name
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Czech description
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Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2017
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Book/collection name
Nutritional Antioxidant Therapies: Treatments and Perspectives
ISBN
978-3-319-67623-4
Number of pages of the result
23
Pages from-to
283-305
Number of pages of the book
553
Publisher name
Springer
Place of publication
Cham
UT code for WoS chapter
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