Effect of six oximes on acutely anticholinesterase inhibitor-induced oxidative stress in rat plasma and brain
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62690094%3A18470%2F18%3A50014111" target="_blank" >RIV/62690094:18470/18:50014111 - isvavai.cz</a>
Result on the web
<a href="https://link.springer.com/article/10.1007%2Fs00204-017-2101-z" target="_blank" >https://link.springer.com/article/10.1007%2Fs00204-017-2101-z</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s00204-017-2101-z" target="_blank" >10.1007/s00204-017-2101-z</a>
Alternative languages
Result language
angličtina
Original language name
Effect of six oximes on acutely anticholinesterase inhibitor-induced oxidative stress in rat plasma and brain
Original language description
Beside the key inhibition of acetylcholinesterase (AChE), involvement of oxidative stress in organophosphate (OP)-induced toxicity has been supported by experimental and human studies. On the other hand, according to our best knowledge, possible antioxidant properties of oximes, the only causal antidotes to OP-inhibited AChE, have been examined only by a few studies. Thus, we have determined the effect of four conventional (obidoxime, trimedoxime, pralidoxime, asoxime) and two promising experimental oximes (K027, K203) on dichlorvos (DDVP)-induced oxidative changes in vivo. Wistar rats (5/group) were treated with oxime (5% LD50 i.m) immediately after DDVP challenge (75% LD50 s.c). Oxidative stress biomarkers were determined in plasma and brain 60 min after the treatment: prooxidative—superoxide anion (O2 ·−) and total oxidative status (TOS); antioxidative—superoxide dismutase (SOD), total thiol (SH) groups, total antioxidant status (TAS) and paraoxonase (PON1); tissue oxidative stress burden—prooxidative–antioxidative balance (PAB) and oxidative stress index (OSI); oxidative tissue damage—malondialdehyde (MDA) and advanced oxidation protein products (AOPP). All oximes were able to attenuate DDVP-induced oxidative stress in rat plasma and brain. Changes of determined parameters in brain were not as prominent as it was seen in plasma. Based on OSI, better abilities of oxime K027, K203 and obidoxime to maintain DDVP-induced oxidative stress in rat brain were shown as compared to trimedoxime, pralidoxime and asoxime. Oximes can influence the complex in vivo redox processes that might contribute to their overall therapeutic efficacy. Further research is needed to understand the underlying molecular mechanisms involved in this phenomenon.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30108 - Toxicology
Result continuities
Project
<a href="/en/project/8F17004" target="_blank" >8F17004: Novel butyrylcholinesterase reactivators for pseudo-catalytic scavenging of organophoshates</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Archives of toxicology
ISSN
0340-5761
e-ISSN
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Volume of the periodical
92
Issue of the periodical within the volume
2
Country of publishing house
DE - GERMANY
Number of pages
13
Pages from-to
745-757
UT code for WoS article
000425526000016
EID of the result in the Scopus database
2-s2.0-85032950416