Profiling donepezil template into multipotent hybrids with antioxidant properties

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62690094%3A18470%2F18%3A50014446" target="_blank" >RIV/62690094:18470/18:50014446 - isvavai.cz</a>
Alternative codes found
RIV/60162694:G44__/18:43889471 RIV/00023752:_____/18:43919338 RIV/00179906:_____/18:10373702
Result on the web
<a href="https://www.ncbi.nlm.nih.gov/pubmed/29529892" target="_blank" >https://www.ncbi.nlm.nih.gov/pubmed/29529892</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1080/14756366.2018.1443326" target="_blank" >10.1080/14756366.2018.1443326</a>

Result language
angličtina
Original language name
Profiling donepezil template into multipotent hybrids with antioxidant properties
Original language description
Alzheimer's disease is debilitating neurodegenerative disorder in the elderly. Current therapy relies on administration of acetylcholinesterase inhibitors (AChEIs) -donepezil, rivastigmine, galantamine, and N-methyl-d-aspartate receptor antagonist memantine. However, their therapeutic effect is only short-term and stabilizes cognitive functions for up to 2 years. Given this drawback together with other pathological hallmarks of the disease taken into consideration, novel approaches have recently emerged to better cope with AD onset or its progression. One such strategy implies broadening the biological profile of AChEIs into so-called multi-target directed ligands (MTDLs). In this review article, we made comprehensive literature survey emphasising on donepezil template which was structurally converted into plethora of MTLDs preserving anti-cholinesterase effect and, at the same time, escalating the anti-oxidant potential, which was reported as a crucial role in the pathogenesis of the Alzheimer's disease. [GRAPHICS] .
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30107 - Medicinal chemistry

Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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