Gastroprotective effects of amifostine in rats treated by T-2 toxin

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62690094%3A18470%2F18%3A50014455" target="_blank" >RIV/62690094:18470/18:50014455 - isvavai.cz</a>
Alternative codes found
RIV/00179906:_____/18:10376313
Result on the web
<a href="http://dx.doi.org/10.1080/15569543.2017.1329211" target="_blank" >http://dx.doi.org/10.1080/15569543.2017.1329211</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1080/15569543.2017.1329211" target="_blank" >10.1080/15569543.2017.1329211</a>

Result language
angličtina
Original language name
Gastroprotective effects of amifostine in rats treated by T-2 toxin
Original language description
Cytoprotector amifostine (AMI) was given in a dose of 50, 100 or 150mg/kg ip in rats treated with several highly toxic doses of T-2 toxin. The best survival rate (24h and 7days after treatment) was obtained with AMI50 (50mg/kg ip). After T-2 intoxication, a peak in the mean number of gastric lesions (petechiae and ulcerations) was reached on the third day (26.40 +/- 6.24). Administration of AMI50 reduced, almost completely, the total number of gastric lesions in rats acutely poisoned by 0.5 LD50 T-2 (1.5mg/kg sc), starting with day 1 after intoxication (5.60 +/- 3.42).
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
30108 - Toxicology

Project
—
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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