Venous Thromboembolism as an Adverse Effect During Treatment With Olanzapine: A Case Series

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62690094%3A18470%2F19%3A50015595" target="_blank" >RIV/62690094:18470/19:50015595 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11150/19:10395571 RIV/00179906:_____/19:10395571

Result on the web

<a href="https://www.frontiersin.org/articles/10.3389/fpsyt.2019.00330/full" target="_blank" >https://www.frontiersin.org/articles/10.3389/fpsyt.2019.00330/full</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3389/fpsyt.2019.00330" target="_blank" >10.3389/fpsyt.2019.00330</a>

Result language

angličtina

Original language name

Venous Thromboembolism as an Adverse Effect During Treatment With Olanzapine: A Case Series

Original language description

Objective: Venous thromboembolism (VTE) is a serious multifactorial disorder. Patients with severe mental illness have a higher risk of developing the condition compared to the general population. Methods: We observed 10 cases of VTE in patients with mental illness who were treated with the antipsychotic drug olanzapine. The diagnosis of VTE was made at the University Hospital Hradec Kralove (UH HK) from 2004 to 2013. VTE was objectively determined by imaging techniques (duplex ultrasonography, CT angiography) and laboratory tests (D-dimer). The average age was 46 years. The clinical manifestation of VTE was deep vein thrombosis in nine cases, including one case of simultaneous pulmonary embolism and one case of a concurrent ischemic cerebrovascular accident (iCVA). None of our patients had a history of malignant disease, trauma, or surgery. Results: Apart from antipsychotic medication, all the patients had clinical or laboratory risk factors for VTE. The most frequent clinical risk factors were obesity (n = 7) and smoking (n = 6). The most frequent laboratory risk factors were increased levels of FVIII (n = 4), mild hyperhomocysteinemia (n = 3), and factor V Leiden mutation (n = 2). VTE developed within 3 months after antipsychotic drug initiation in three patients and within 6 months in three patients. Conclusion: Olanzapine can be considered a precipitating factor for VTE formation. When olanzapine is administered, we need to monitor for clinical signs and symptoms of VTE, especially when other risk factors are present.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30104 - Pharmacology and pharmacy

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2019

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

FRONTIERS IN PSYCHIATRY

ISSN

1664-0640

e-ISSN

—

Volume of the periodical

10

Issue of the periodical within the volume

MAY

Country of publishing house

CH - SWITZERLAND

Number of pages

6

Pages from-to

1-6

UT code for WoS article

000468147700001

EID of the result in the Scopus database

2-s2.0-85068220655