Slight difference in the isomeric oximes K206 and K203 makes huge difference for the reactivation of organophosphorus-inhibited AChE: Theoretical and experimental aspects
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62690094%3A18470%2F19%3A50015739" target="_blank" >RIV/62690094:18470/19:50015739 - isvavai.cz</a>
Alternative codes found
RIV/00179906:_____/19:10397171
Result on the web
<a href="https://www.sciencedirect.com/science/article/pii/S0009279719302959?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0009279719302959?via%3Dihub</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.cbi.2019.05.037" target="_blank" >10.1016/j.cbi.2019.05.037</a>
Alternative languages
Result language
angličtina
Original language name
Slight difference in the isomeric oximes K206 and K203 makes huge difference for the reactivation of organophosphorus-inhibited AChE: Theoretical and experimental aspects
Original language description
Studies with oximes have been extensively developed to design new reactivators with better efficiency, and greater spectrum of action. In this study, we aimed to analyze the influence of the Carbamoyl group position change in two isomeric oximes, K203 and K206, on the reactivation percentage of Mus musculus Acetylcholinesterase (MmAChE), inhibited by different nerve agents. Theoretical calculations were performed to assess the difference for the oxime activity with inhibited AChE-complexes and the factors that govern this difference. Comparing theoretical and experimental data, it is possible to observe that this change between the oximes results in different reactivation percentage for the same nerve agent, due to the different interaction modes and activation energy for the studied systems.
Czech name
—
Czech description
—
Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
30108 - Toxicology
Result continuities
Project
<a href="/en/project/NV16-34390A" target="_blank" >NV16-34390A: Development of new environment friendly insecticides against malaria mosquito</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Chemico-biological interactions
ISSN
0009-2797
e-ISSN
—
Volume of the periodical
309
Issue of the periodical within the volume
August
Country of publishing house
IE - IRELAND
Number of pages
7
Pages from-to
"Article Number: 108671"
UT code for WoS article
000482178500001
EID of the result in the Scopus database
2-s2.0-85067563170