Analyses of biomarkers of exposure to nephrotoxic mycotoxins in a cohort of patients with renal tumours

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62690094%3A18470%2F19%3A50016040" target="_blank" >RIV/62690094:18470/19:50016040 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11150/19:10399781 RIV/00179906:_____/19:10399781 RIV/75010330:_____/19:00012695

Result on the web

<a href="https://link.springer.com/article/10.1007/s12550-019-00365-9" target="_blank" >https://link.springer.com/article/10.1007/s12550-019-00365-9</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s12550-019-00365-9" target="_blank" >10.1007/s12550-019-00365-9</a>

Result language

angličtina

Original language name

Analyses of biomarkers of exposure to nephrotoxic mycotoxins in a cohort of patients with renal tumours

Original language description

The Czech Republic occupies the first place in the world in the frequency of renal and other urinary tract tumours, but their aetiology is unknown. To explore whether carcinogenic and nephrotoxic mycotoxins may contribute to kidney diseases in the Czech population, biomarkers of ochratoxin A (OTA) and citrinin (CIT) exposure were determined in biological specimens from a cohort of 50 patients with malignant renal tumours. Biomarker analyses in blood and urine samples used validated targeted methods for measuring OTA and CIT plus dihydrocitrinone (DH-CIT) after enrichment of analytes by specific immunoaffinity clean-up. OTA and CIT plus its metabolite DH-CITwere frequently detected in patient urine samples (OTA 62%; CIT 91%; DHCIT 100%). The concentration ranges in urine were 1–27.8 ng/L for OTA, 2–87 ng/L for CIT and 2–160 ng/L for DH-CIT. The analyses of blood samples revealed also a frequent co-occurrence of OTA and CIT, in the ranges of 40–870 ng/L serum for OTA and 21–182 ng/L plasma for CIT. This first analysis of biomarkers in blood and urine samples of Czech patients revealed no major differences in comparison with published data for the general healthy Czech and European populations. Nonetheless, a frequent co-occurrence of CIT and OTA biomarkers in patient samples may be of interest with regard to potential interactions with other risk factors for renal disease.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

10620 - Other biological topics

Project

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Continuities

S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2019

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Mycotoxin research

ISSN

0178-7888

e-ISSN

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Volume of the periodical

35

Issue of the periodical within the volume

4

Country of publishing house

DE - GERMANY

Number of pages

13

Pages from-to

391-403

UT code for WoS article

000491496300008

EID of the result in the Scopus database

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