Investigation of ochratoxin A biomarkers in biological materials obtained from patients suffering from renal cell carcinoma

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62690094%3A18470%2F21%3A50018643" target="_blank" >RIV/62690094:18470/21:50018643 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11150/21:10435166 RIV/75010330:_____/21:00013602 RIV/00179906:_____/21:10435166

Result on the web

<a href="https://www.sciencedirect.com/science/article/pii/S027869152100702X?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S027869152100702X?via%3Dihub</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.fct.2021.112669" target="_blank" >10.1016/j.fct.2021.112669</a>

Result language

angličtina

Original language name

Investigation of ochratoxin A biomarkers in biological materials obtained from patients suffering from renal cell carcinoma

Original language description

Ochratoxin A (OTA) exposure can result in chronic renal diseases and cancer. The incidence of kidney, renal pelvis, and ureter malignant neoplasms in the Czech Republic is approximately 29.5 renal tumours per 100,000 inhabitants. The question arises whether mycotoxins are also involved in kidney disease and cancer. A sensitive validated analytical methodology, based on an immunoaffinity clean-up followed by HPLC with fluorescence detection, was developed to explore whether OTA accumulates in clear renal cell carcinoma-adenocarcinoma in Czech patients. Simultaneously, DNA-adducts and OTA metabolites were qualitatively analysed in tissues and urine. OTA was analysed in 33 kidney and tumour samples from 26 men and 7 women collected during nephrectomy from patients of the East Bohemian region from 2015 to 2017. OTA was found in 76% of the analysed samples. Its concentrations ranged from not detectable to 390 ng/kg with a median of 167 ng/kg in kidney samples and from not detectable to 430 ng/kg with a median of 122 ng/kg in tumour samples. Urinary OTA metabolites and DNA adducts were qualitatively analysed for the corresponding 20 patients. The presence of some OTA metabolites such as ochratoxin A hydroquinone and/or decarboxylated ochratoxin A hydroquinone correlate with the presence of OTA-DNA adducts.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

10620 - Other biological topics

Project

—

Continuities

S - Specificky vyzkum na vysokych skolach

Publication year

2021

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Food and chemical toxicology

ISSN

0278-6915

e-ISSN

—

Volume of the periodical

158

Issue of the periodical within the volume

DEC

Country of publishing house

GB - UNITED KINGDOM

Number of pages

13

Pages from-to

"Article Number: 112669"

UT code for WoS article

000721182800005

EID of the result in the Scopus database

2-s2.0-85119043819