Nerve Agents' Surrogates: Invaluable Tools for Development of Acetylcholinesterase Reactivators

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62690094%3A18470%2F19%3A50016114" target="_blank" >RIV/62690094:18470/19:50016114 - isvavai.cz</a>

Result on the web

<a href="https://www.ingentaconnect.com/content/ben/coc/2019/00000023/00000014/art00007" target="_blank" >https://www.ingentaconnect.com/content/ben/coc/2019/00000023/00000014/art00007</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.2174/1385272823666190806114017" target="_blank" >10.2174/1385272823666190806114017</a>

Result language

angličtina

Original language name

Nerve Agents' Surrogates: Invaluable Tools for Development of Acetylcholinesterase Reactivators

Original language description

The use of nerve agents as warfare and in terrorist acts has drawn much attention from the governments and societies. Such toxic organophosphorus compounds are listed in Chemical Weapons Convention as Schedule 1 chemicals. The discussion about the chemical identity of the elusive Novichok agents, more potent compounds than best known G- and V-Agents, which have been implicated in recent rumorous assassination plots, clearly demonstrating the importance of the matter. Furthermore, accidents with pesticides or misuse thereof have been a pressing issue in many countries. In this context, the continued development of novel cholinesterase reactivators, antidotes for organophosphorus poisoning, a rather restricted class of pharmaceutical substances, is warranted. Testing of novel candidates may require use of actual nerve agents. Nonetheless, only a few laboratories comply with the requirements for storing, possession and manipulation of such toxic chemicals. To overcome such limitations, nerve agents&apos; surrogates may be a useful alternative, as they undergo the same reaction with cholinesterases, yielding similar adducts, allowing assays with novel antidote candidates, among other applications.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30108 - Toxicology

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2019

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Current organic chemistry

ISSN

1385-2728

e-ISSN

—

Volume of the periodical

23

Issue of the periodical within the volume

14

Country of publishing house

AE - UNITED ARAB EMIRATES

Number of pages

21

Pages from-to

1539-1559

UT code for WoS article

000490547000006

EID of the result in the Scopus database

2-s2.0-85076517628