Novel Cholinesterase Reactivators

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62690094%3A18470%2F20%3A50017538" target="_blank" >RIV/62690094:18470/20:50017538 - isvavai.cz</a>
Result on the web
<a href="https://www.sciencedirect.com/book/9780128190906/handbook-of-toxicology-of-chemical-warfare-agents" target="_blank" >https://www.sciencedirect.com/book/9780128190906/handbook-of-toxicology-of-chemical-warfare-agents</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/B978-0-12-819090-6.00069-6" target="_blank" >10.1016/B978-0-12-819090-6.00069-6</a>

Result language
angličtina
Original language name
Novel Cholinesterase Reactivators
Original language description
The continuous threat of organophosphorus (OP) nerve agent misuse supports the development of antidotes with enhanced potency. In this chapter, we focus on antidotal therapy with cholinesterase reactivators. Although this group of compounds has been known for more than a halfcentury, there is no single compound that might counteract every nerve agent’s lethal effects. This chapter describes in detail the design and synthesis of the cholinesterase reactivators that have been developed within the last decade. Within the design of novel molecules, special emphasis is placed on the structural requirements (structure-activity relationship) of these compounds. Finally, several new trends in the development of new reactivators are discussed.
Czech name
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Czech description
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Project
<a href="/en/project/GA19-13628S" target="_blank" >GA19-13628S: Encapsulation of cholinesterase reactivators using apoferritin for enhanced bioavailability in central nervous system</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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