Novel Cholinesterase Reactivators

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62690094%3A18470%2F15%3A50004583" target="_blank" >RIV/62690094:18470/15:50004583 - isvavai.cz</a>
Alternative codes found
RIV/60162694:G44__/15:43875314 RIV/00179906:_____/15:10320699
Result on the web
<a href="http://dx.doi.org/10.1016/B978-0-12-800159-2.00072-5" target="_blank" >http://dx.doi.org/10.1016/B978-0-12-800159-2.00072-5</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/B978-0-12-800159-2.00072-5" target="_blank" >10.1016/B978-0-12-800159-2.00072-5</a>

Result language
angličtina
Original language name
Novel Cholinesterase Reactivators
Original language description
The continuous threat of organophosphorus (OP) nerve agent misuse supports the development of antidotes with enhanced potency. In this chapter, we are focusing on antidotal therapy with acetylcholinesterase (AChE) reactivators. Although this group of compounds has been known for more than a half-century, there is no single compound that might counteract every nerve agent's lethal effects. This chapter describes in detail the design and synthesis of the AChE reactivators that have been developed within the last two decades. Within the design of novel molecules, special emphasis is placed on the structural requirements (structure-activity relationship) of these compounds. Finally, several new trends in the development of new reactivators are discussed.
Czech name
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Czech description
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Project
<a href="/en/project/LH13009" target="_blank" >LH13009: The research of modified cholinesterase reactivators for organophosphorus pesticide poisoning treatment</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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