The hunt for radiation biomarkers: current situation
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62690094%3A18470%2F20%3A50016194" target="_blank" >RIV/62690094:18470/20:50016194 - isvavai.cz</a>
Alternative codes found
RIV/60162694:G44__/20:00555431
Result on the web
<a href="https://www.tandfonline.com/doi/abs/10.1080/09553002.2020.1704909?journalCode=irab20" target="_blank" >https://www.tandfonline.com/doi/abs/10.1080/09553002.2020.1704909?journalCode=irab20</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1080/09553002.2020.1704909" target="_blank" >10.1080/09553002.2020.1704909</a>
Alternative languages
Result language
angličtina
Original language name
The hunt for radiation biomarkers: current situation
Original language description
Purpose: The possibility of a large-scale acute radiation exposure necessitates the development of new methods that could provide a rapid assessment of the doses received by individuals using high-throughput technologies. There is also a great interest in developing new biomarkers of dose exposure, which could be used in large molecular epidemiological studies in order to correlate estimated doses received and health effects. The goal of this review was to summarize current literature focused on biological dosimetry, namely radiation-responsive biomarkers. Methods: The studies involved in this review were thoroughly selected according to the determined criteria and PRISMA guidelines. Results: We described briefly recent advances in radiation genomics and metabolomics, giving particular emphasis to proteomic analysis. The majority of studies were performed on animal models (rats, mice, and non-human primates). They have provided much beneficial information, but the most relevant tests have been done on human (oncological) patients. By inspecting the radiaiton biodosimetry literate of the last 10years, we identified a panel of candidate markers for each –omic approach involved. Conslusions: We reviewed different methodological approaches and various biological materials, which can be exploited for dose-effect prediction. The protein biomarkers from human plasma are ideal for this specific purpose. From a plethora of candidate markers, FDXR is a very promising transcriptomic candidate, and importantly this biomarker was also confirmed by some studies at protein level in humans.
Czech name
—
Czech description
—
Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
10609 - Biochemical research methods
Result continuities
Project
—
Continuities
S - Specificky vyzkum na vysokych skolach
Others
Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
International journal of radiation biology
ISSN
0955-3002
e-ISSN
—
Volume of the periodical
96
Issue of the periodical within the volume
3
Country of publishing house
GB - UNITED KINGDOM
Number of pages
13
Pages from-to
370-382
UT code for WoS article
000516972500009
EID of the result in the Scopus database
2-s2.0-85077843182