Proteomics in Huntington’s Disease Biomarker Discovery
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985904%3A_____%2F23%3A00577184" target="_blank" >RIV/67985904:_____/23:00577184 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1007/978-3-031-32815-2_9" target="_blank" >http://dx.doi.org/10.1007/978-3-031-32815-2_9</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/978-3-031-32815-2_9" target="_blank" >10.1007/978-3-031-32815-2_9</a>
Alternative languages
Result language
angličtina
Original language name
Proteomics in Huntington’s Disease Biomarker Discovery
Original language description
Mass spectrometry (MS) and proteomics are continuously evolving methods in systems biology that carry enormous potential for accurately profiling the proteome of diseased tissues and exploring biomarker molecules. In Huntington’s disease (HD), the identification of novel effective biomarkers for monitoring the disease progression from the early asymptomatic stage would be extremely useful for clinical decision-making. Although none of the detected candidate molecules has reached the level of validation, available proteomic studies have provided a list of potential protein biomarkers for future targeted studies using modern workflows in large clinical trials. This review summarises protein data from HD patients and experimental models, reporting biomarker candidates verified by independent methods or identified by multiple independent studies. After examining the overlaps across different tissues and models, several known and novel candidates emerged as consistently affected in HD. Based on MS-based HD studies, we propose the monitoring of existing markers mutant Huntingtin (mHTT) and neurofilament light polypeptide (NfL), together with novel candidate markers, such as proenkephalin-A (PENK), proenkephalin-B (PDYN), glial fibrillary acidic protein (GFAP), and many others.
Czech name
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Czech description
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Classification
Type
C - Chapter in a specialist book
CEP classification
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OECD FORD branch
10608 - Biochemistry and molecular biology
Result continuities
Project
<a href="/en/project/EF16_019%2F0000785" target="_blank" >EF16_019/0000785: Center for Tumor Ecology - Research of the cancer microenvironment supporting cancer growth and spread</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2023
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Book/collection name
Biomarkers for Huntington's Disease
ISBN
978-3-031-32814-5
Number of pages of the result
38
Pages from-to
209-247
Number of pages of the book
475
Publisher name
Springer
Place of publication
Cham
UT code for WoS chapter
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