Targeted proteomics in translational research of neurodegenerative diseases

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985904%3A_____%2F20%3A00536527" target="_blank" >RIV/67985904:_____/20:00536527 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Targeted proteomics in translational research of neurodegenerative diseases
Original language description
With recent technical improvements in the field of mass spectrometry-based analysis of proteins, the technology is now ready to enter clinical laboratories for routine measurements of protein biomarkers. Targeted MS methods like selected reaction monitoring or recently presented parallel reaction monitoring showed a great potential for sensitive, selective, and robust assays. Ease of development and multiplexing capacity of these methods is especially suitable for verification and validation of proteomics discovery data. The translation of preclinical findings in research of neurodegenerative disorders into practical use now relies on necessary implementation of independent tightly controlled clinical studies on a large cohort of well-defined subjects. In our review we briefly describe the targeted proteomics techniques and their employment in clinical proteomics validation of neurodegeneration biomarkers, with hope to identify disease diagnostic, prognostic or predictive biomarkers.
Czech name
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Czech description
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Project
<a href="/en/project/LO1609" target="_blank" >LO1609: Models of the Serious Human Diseases: Traumatic Spinal Cord Injury, Huntington’s Disease, Melanoma and Infertility</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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