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Wide-Antimicrobial Spectrum of Picolinium Salts

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62690094%3A18470%2F20%3A50016826" target="_blank" >RIV/62690094:18470/20:50016826 - isvavai.cz</a>

  • Alternative codes found

    RIV/68378050:_____/20:00525589 RIV/60162694:G44__/20:00555750 RIV/00179906:_____/20:10412307

  • Result on the web

    <a href="https://www.mdpi.com/1420-3049/25/9/2254" target="_blank" >https://www.mdpi.com/1420-3049/25/9/2254</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.3390/molecules25092254" target="_blank" >10.3390/molecules25092254</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Wide-Antimicrobial Spectrum of Picolinium Salts

  • Original language description

    Nosocomial infections, which greatly increase morbidity among hospitalized patients, together with growing antibiotic resistance still encourage many researchers to search for novel antimicrobial compounds. Picolinium salts with different lengths of alkyl chains (C-12, C-14, C-16) were prepared by Menshutkin-like reaction and evaluated with respect to their biological activity, i.e., lipophilicity and critical micellar concentration. Picolinium salts with C-14 and C-16 side chains achieved similar or even better results when in terms of antimicrobial efficacy than benzalkoniums; notably, their fungicidal efficiency was substantially more potent. The position of the methyl substituent on the aromatic ring does not seem to affect antimicrobial activity, in contrast to the effect of length of the N-alkyl chain. Concurrently, picolinium salts exhibited satisfactory low cytotoxicity against mammalian cells, i.e., lower than that of benzalkonium compounds, which are considered as safe.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    10608 - Biochemistry and molecular biology

Result continuities

  • Project

    <a href="/en/project/NV19-09-00198" target="_blank" >NV19-09-00198: Development of novel quaternary ammonium compounds against microbial biofilm in oral cavity</a><br>

  • Continuities

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2020

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    MOLECULES

  • ISSN

    1420-3049

  • e-ISSN

  • Volume of the periodical

    25

  • Issue of the periodical within the volume

    9

  • Country of publishing house

    CH - SWITZERLAND

  • Number of pages

    16

  • Pages from-to

    "Article Number: 2254"

  • UT code for WoS article

    000535695900250

  • EID of the result in the Scopus database

    2-s2.0-85084415087