Wide-Antimicrobial Spectrum of Picolinium Salts
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62690094%3A18470%2F20%3A50016826" target="_blank" >RIV/62690094:18470/20:50016826 - isvavai.cz</a>
Alternative codes found
RIV/68378050:_____/20:00525589 RIV/60162694:G44__/20:00555750 RIV/00179906:_____/20:10412307
Result on the web
<a href="https://www.mdpi.com/1420-3049/25/9/2254" target="_blank" >https://www.mdpi.com/1420-3049/25/9/2254</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3390/molecules25092254" target="_blank" >10.3390/molecules25092254</a>
Alternative languages
Result language
angličtina
Original language name
Wide-Antimicrobial Spectrum of Picolinium Salts
Original language description
Nosocomial infections, which greatly increase morbidity among hospitalized patients, together with growing antibiotic resistance still encourage many researchers to search for novel antimicrobial compounds. Picolinium salts with different lengths of alkyl chains (C-12, C-14, C-16) were prepared by Menshutkin-like reaction and evaluated with respect to their biological activity, i.e., lipophilicity and critical micellar concentration. Picolinium salts with C-14 and C-16 side chains achieved similar or even better results when in terms of antimicrobial efficacy than benzalkoniums; notably, their fungicidal efficiency was substantially more potent. The position of the methyl substituent on the aromatic ring does not seem to affect antimicrobial activity, in contrast to the effect of length of the N-alkyl chain. Concurrently, picolinium salts exhibited satisfactory low cytotoxicity against mammalian cells, i.e., lower than that of benzalkonium compounds, which are considered as safe.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10608 - Biochemistry and molecular biology
Result continuities
Project
<a href="/en/project/NV19-09-00198" target="_blank" >NV19-09-00198: Development of novel quaternary ammonium compounds against microbial biofilm in oral cavity</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
MOLECULES
ISSN
1420-3049
e-ISSN
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Volume of the periodical
25
Issue of the periodical within the volume
9
Country of publishing house
CH - SWITZERLAND
Number of pages
16
Pages from-to
"Article Number: 2254"
UT code for WoS article
000535695900250
EID of the result in the Scopus database
2-s2.0-85084415087