Anorexic responses to trichothecene deoxynivalenol and its congeners correspond to secretion of tumor necrosis factor-alpha and interleukin-1 beta

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62690094%3A18470%2F20%3A50016843" target="_blank" >RIV/62690094:18470/20:50016843 - isvavai.cz</a>

Result on the web

<a href="https://www.sciencedirect.com/science/article/pii/S1382668920300478?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S1382668920300478?via%3Dihub</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.etap.2020.103371" target="_blank" >10.1016/j.etap.2020.103371</a>

Result language

angličtina

Original language name

Anorexic responses to trichothecene deoxynivalenol and its congeners correspond to secretion of tumor necrosis factor-alpha and interleukin-1 beta

Original language description

Type B trichothecene mycotoxins comprise deoxynivalenol (&quot;Vomitoxin&quot;, DON) and four structually related congeners: 15-acetyl- and 3-acetyl-deoxynivalenol (15-ADON and 3-ADON), nivalenol (NIV), 4-acetyl-nivalenol (fusarenon X, FX). These foodborne mycotoxins has been linked to food poisoning leading to anorexic response in human and several animal species. However, the pathophysiological basis for anorexic effect is relatively unclear. The goal of this research was to compare anorexic effect to type B trichothecenes and relate these effects to two common cytokines tumor necrosis factor-alpha (TNF-alpha) and interleukin-1 beta (IL-1 beta) following oral and IP exposure. Both cytokines were increased within 1-2 h in plasma and returned to basal concentrations at 6 h following exposure to DON and ADONs. FX evoked both cytokines with initial time and duration at 1-2 h and &gt; 6 h, respectively. Elevation of TNF-alpha and IL-1 beta induced by orally exposure to NIV did not occur until 2 h and recovered to basal concentrations at 6 h. Both cytokines were elevated at 1 h and lasted more than 6 h following IP exposure to NIV. Type B trichothecenes stimulated plasma secretion of both cytokines that were consistent with reduction of food intake. In conclusion, our findings demonstrate that TNF-alpha and IL-1 beta act critical roles in type B trichothecenes-induced anorexic response.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30108 - Toxicology

Project

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Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2020

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY

ISSN

1382-6689

e-ISSN

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Volume of the periodical

77

Issue of the periodical within the volume

JUL

Country of publishing house

NL - THE KINGDOM OF THE NETHERLANDS

Number of pages

8

Pages from-to

"Article Number: 103371"

UT code for WoS article

000537596500004

EID of the result in the Scopus database

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