Biomarkers of deoxynivalenol (DON) and its modified form DON-3-glucoside (DON-3G) in humans
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62690094%3A18470%2F21%3A50017903" target="_blank" >RIV/62690094:18470/21:50017903 - isvavai.cz</a>
Result on the web
<a href="https://www.sciencedirect.com/science/article/pii/S0924224421001448?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0924224421001448?via%3Dihub</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.tifs.2021.02.038" target="_blank" >10.1016/j.tifs.2021.02.038</a>
Alternative languages
Result language
angličtina
Original language name
Biomarkers of deoxynivalenol (DON) and its modified form DON-3-glucoside (DON-3G) in humans
Original language description
Background: To date, considerable research has been devoted to biomarkers of deoxynivalenol (DON) and its modified form DON-3-glucoside (DON-3G) in humans. Since these both cause toxic effects in humans, identifying the biomarkers of these toxins is crucial for human health. Scope and approach: In the present review, we systematically assess the profiles of human DON biomarkers in different regions, ages, sexes, and dietary habits; the specific features of DON biomarkers in pregnant women are discussed separately. We highlight recent advances in our knowledge of human DON-3G biomarkers. Key findings and conclusions: Free DON and DON-glucuronide (DON-GlcA) are the major biomarkers of DON in human urine, whereas DON-3-sulphate and the deepoxy product DOM-1 are the secondary biomarkers. The amount of DON exposure in children and adolescents is higher than that in adults, whereas the elderly show the lowest levels, suggesting that young people, including children, face greater health risks from this toxin. DON can cross the placental barrier from mothers and may inhibit foetal growth and immune function. The vegetarian population shows a higher risk of exposure to DON and DON-3G due to their greater consumption of vegetables and cereals. Animal studies show that females excrete DON and its principal metabolites, including DON-3-GlcA, in their urine more rapidly than males. DON-15-GlcA is the most prominent urinary biomarker of DON-3G. This review should help to further understanding the specific profiles of human DON and DON-3G biomarkers. © 2021 Elsevier Ltd
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
21101 - Food and beverages
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Trends in Food Science and Technology
ISSN
0924-2244
e-ISSN
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Volume of the periodical
110
Issue of the periodical within the volume
April
Country of publishing house
GB - UNITED KINGDOM
Number of pages
8
Pages from-to
551-558
UT code for WoS article
000632854800007
EID of the result in the Scopus database
2-s2.0-85101374632