Deoxynivalenol (Vomitoxin)-induced anorexia is induced by the release of intestinal hormones in mice
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62690094%3A18470%2F21%3A50018239" target="_blank" >RIV/62690094:18470/21:50018239 - isvavai.cz</a>
Alternative codes found
RIV/00179906:_____/21:10431120
Result on the web
<a href="https://www.mdpi.com/2072-6651/13/8/512" target="_blank" >https://www.mdpi.com/2072-6651/13/8/512</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3390/toxins13080512" target="_blank" >10.3390/toxins13080512</a>
Alternative languages
Result language
angličtina
Original language name
Deoxynivalenol (Vomitoxin)-induced anorexia is induced by the release of intestinal hormones in mice
Original language description
Deoxynivalenol (DON), also known as vomitoxin, is a mycotoxin that can cause antifeeding and vomiting in animals. However, the mechanism of DON inducing anorexia is complicated. Studies have shown that intestinal hormones play a significant part in the anorexia caused by DON. We adopted the “modeling of acute antifeeding in mice” as the basic experimental model, and used two methods of gavage and intraperitoneal injection to explore the effect of intestinal hormones on the antifeedant response induced by DON in mice. We found that 1 and 2.5 mg/kg·bw of DON can acutely induce anorexia and increase the plasma intestinal hormones CCK, PYY, GIP, and GLP-1 in mice within 3 h. Direct injection of exogenous intestinal hormones CCK, PYY, GIP, and GLP-1 can trigger anorexia behavior in mice. Furthermore, the PYY receptor antagonist JNJ-31020028, GLP-1 receptor antagonist Exendin(9-39), CCK receptor antagonist Proglumide, GIP receptor antagonist GIP(3-30)NH2 attenuated both intestinal hormone and DON-induced anorectic responses. These results indicate that intestinal hormones play a critical role in the anorexia response induced by DON. © 2021 by the authors. Licensee MDPI, Basel, Switzerland.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30108 - Toxicology
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Toxins
ISSN
2072-6651
e-ISSN
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Volume of the periodical
13
Issue of the periodical within the volume
8
Country of publishing house
CH - SWITZERLAND
Number of pages
14
Pages from-to
"Article number 512"
UT code for WoS article
000689956500001
EID of the result in the Scopus database
2-s2.0-85111469392