Fused Deposition Modeling as a Possible Approach for the Preparation of Orodispersible Tablets

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62690094%3A18470%2F22%3A50018977" target="_blank" >RIV/62690094:18470/22:50018977 - isvavai.cz</a>

Alternative codes found

RIV/60461373:22340/22:43922574 RIV/00216208:11160/22:10450136

Result on the web

<a href="https://www.mdpi.com/1424-8247/15/1/69" target="_blank" >https://www.mdpi.com/1424-8247/15/1/69</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3390/ph15010069" target="_blank" >10.3390/ph15010069</a>

Result language

angličtina

Original language name

Fused Deposition Modeling as a Possible Approach for the Preparation of Orodispersible Tablets

Original language description

Additive manufacturing technologies are considered as a potential way to support individualized pharmacotherapy due to the possibility of the production of small batches of customized tablets characterized by complex structures. We designed five different shapes and analyzed the effect of the surface/mass ratio, the influence of excipients, and storage conditions on the disintegration time of tablets printed using the fused deposition modeling method. As model pharmaceutical active ingredients (APIs), we used paracetamol and domperidone, characterized by different thermal properties, classified into the various Biopharmaceutical Classification System groups. We found that the high surface/mass ratio of the designed tablet shapes together with the addition of mannitol and controlled humidity storage conditions turned out to be crucial for fast tablet&apos;s disintegration. As a result, mean disintegration time was reduced from 5 min 46 s to 2 min 22 s, and from 11 min 43 s to 2 min 25 s for paracetamol- and domperidone-loaded tablets, respectively, fulfilling the European Pharmacopeia requirement for orodispersible tablets (ODTs). The tablet&apos;s immediate release characteristics were confirmed during the dissolution study: over 80% of APIs were released from printlets within 15 min. Thus, this study proved the possibility of using fused deposition modeling for the preparation of ODTs.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30107 - Medicinal chemistry

Project

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Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2022

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

PHARMACEUTICALS

ISSN

1424-8247

e-ISSN

1424-8247

Volume of the periodical

15

Issue of the periodical within the volume

1

Country of publishing house

CH - SWITZERLAND

Number of pages

21

Pages from-to

"Article Number: 69"

UT code for WoS article

000748828200001

EID of the result in the Scopus database

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