Essential metals in health and disease

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62690094%3A18470%2F22%3A50019426" target="_blank" >RIV/62690094:18470/22:50019426 - isvavai.cz</a>

Alternative codes found

RIV/00179906:_____/22:10449528

Result on the web

<a href="https://www.sciencedirect.com/science/article/abs/pii/S0009279722003787" target="_blank" >https://www.sciencedirect.com/science/article/abs/pii/S0009279722003787</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.cbi.2022.110173" target="_blank" >10.1016/j.cbi.2022.110173</a>

Result language

angličtina

Original language name

Essential metals in health and disease

Original language description

In total, twenty elements appear to be essential for the correct functioning of the human body,half of which are metals and half are non-metals. Among those metals that are currentlyconsidered to be essential for normal biological functioning are four main group elements,sodium (Na), potassium (K), magnesium (Mg), and calcium (Ca), and six d-block transition metalelements, manganese (Mn), iron (Fe), cobalt (Co), copper (Cu), zinc (Zn) and molybdenum (Mo).Cells have developed various metallo-regulatory mechanisms for maintaining a necessaryhomeostasis of metal-ions for diverse cellular processes, most importantly in the central nervoussystem. Since redox active transition metals (for example Fe and Cu) may participate in electrontransfer reactions, their homeostasis must be carefully controlled. The catalytic behaviour ofredox metals which have escaped control, e.g. via the Fenton reaction, results in the formationof reactive hydroxyl radicals, which may cause damage to DNA, proteins and membranes.Transition metals are integral parts of the active centres of numerous enzymes (e.Dg. Cu,Zn-SOD,Mn-SOD, Catalase) which catalyze chemical reactions at physiologically compatible rates. Eithera deficiency, or an excess of essential metals may result in various disease states arising in anorganism. Some typical ailments that are characterized by a disturbed homeostasis of redoxactive metals include neurological disorders (Alzheimer’s, Parkinson’s and Huntington’sdisorders), mental health problems, cardiovascular diseases, cancer, and diabetes. Tocomprehend more deeply the mechanisms by which essential metals, acting either alone or incombination, and/or through their interaction with non-essential metals (e.g. chromium)function in biological systems will require the application of a broader, more interdisciplinaryapproach than has mainly been used so far. It is clear that a stronger cooperation betweenbioinorganic chemists and biophysicists - who have already achieved great success inunderstanding the structure and role of metalloenzymes in living systems - with biologists, willaccess new avenues of research in the systems biology of metal ions. With this in mind, thepresent paper reviews selected chemical and biological aspects of metal ions and their possibleinteractions in living systems under normal and pathological conditions.

Czech name

—

Czech description

—

Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30108 - Toxicology

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2022

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Chemico-biological interactions

ISSN

0009-2797

e-ISSN

1872-7786

Volume of the periodical

367

Issue of the periodical within the volume

November

Country of publishing house

IE - IRELAND

Number of pages

28

Pages from-to

"Article number: 110173"

UT code for WoS article

000868270300005

EID of the result in the Scopus database

2-s2.0-85138599128