HIF-1 alpha inhibits T-2 toxin-mediated "immune evasion" process by negatively regulating PD-1/PD-L1

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62690094%3A18470%2F22%3A50019462" target="_blank" >RIV/62690094:18470/22:50019462 - isvavai.cz</a>

Result on the web

<a href="https://www.sciencedirect.com/science/article/pii/S0300483X22002360?pes=vor" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0300483X22002360?pes=vor</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.tox.2022.153324" target="_blank" >10.1016/j.tox.2022.153324</a>

Result language

angličtina

Original language name

HIF-1 alpha inhibits T-2 toxin-mediated "immune evasion" process by negatively regulating PD-1/PD-L1

Original language description

Trichothecene mycotoxins have a strong immunosuppressive effect, which may even escape host immune surveillance and damage the immune repair to show an “immune evasion&quot; effect. Increasing lines of evidence have shown that hypoxia and hypoxia-inducible factors (HIFs) are key mediators of trichothecenes, and these toxins appear to be closely related to the “immune evasion” mechanisms. Therefore, we used RAW264.7 cell model to explore the association of T-2 toxins with “immune evasion” process and hypoxia, as well as their cross-linking effects induced by T-2 toxin. Our results showed that HIF-1α is an important toxicity target of T-2 toxin, which could induce intracellular hypoxia. T-2 toxin induced an “immune evasion” process by activating the PD-1/PD-L1 signaling pathway. Interestingly, when HIF-1α activation was blocked, the “immune evasion” process regulated by PD-1/PD-L1 signaling was activated, resulting in the cells damage, suggesting that hypoxia induced by T-2 toxin plays a protective role for RAW264.7 cell damage. Thus, our work shows that HIF-1α inhibits T-2 toxin-mediated “immune evasion” process by negatively regulating PD-1/PD-L1signaling. This study contributes to a better understanding of the immunotoxicity mechanism of trichothecenes. © 2022 Elsevier B.V.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30108 - Toxicology

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2022

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Toxicology

ISSN

0300-483X

e-ISSN

1879-3185

Volume of the periodical

480

Issue of the periodical within the volume

October

Country of publishing house

IE - IRELAND

Number of pages

11

Pages from-to

"Article number: 153324"

UT code for WoS article

000901662900003

EID of the result in the Scopus database

2-s2.0-85138619604