Metformin: Activation of 5′ AMP-activated protein kinase and its emerging potential beyond anti-hyperglycemic action
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62690094%3A18470%2F22%3A50019646" target="_blank" >RIV/62690094:18470/22:50019646 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11150/22:10449564 RIV/00179906:_____/22:10449564
Result on the web
<a href="https://www.frontiersin.org/articles/10.3389/fgene.2022.1022739/full" target="_blank" >https://www.frontiersin.org/articles/10.3389/fgene.2022.1022739/full</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3389/fgene.2022.1022739" target="_blank" >10.3389/fgene.2022.1022739</a>
Alternative languages
Result language
angličtina
Original language name
Metformin: Activation of 5′ AMP-activated protein kinase and its emerging potential beyond anti-hyperglycemic action
Original language description
Metformin is a plant-based drug belonging to the class of biguanides and is known to treat type-2 diabetes mellitus (T2DM). The drug, combined with controlling blood glucose levels, improves the body’s response to insulin. In addition, trials have identified the cardioprotective potential of metformin in the diabetic population receiving the drug. Activation of 5′ AMP-activated protein kinase (AMPK) is the major pathway for these potential beneficial effects of metformin. Historically, much emphasis has been placed on the potential indications of metformin beyond its anti-diabetic use. This review aims to appraise other potential uses of metformin primarily mediated by the activation of AMPK. We also discuss various mechanisms, other than AMPK activation, by which metformin could produce beneficial effects for different conditions. Databases including PubMed/MEDLINE and Embase were searched for literature relevant to the review’s objective. Reports from both research and review articles were considered. We found that metformin has diverse effects on the human body systems. It has been shown to exert anti-inflammatory, antioxidant, cardioprotective, metabolic, neuroprotective, anti-cancer, and antimicrobial effects and has now even been identified as effective against SARS-CoV-2. Above all, the AMPK pathway has been recognized as responsible for metformin’s efficiency and effectiveness. Owing to its extensive potential, it has the capability to become a part of treatment regimens for diseases apart from T2DM. Copyright © 2022 Goel, Singh, Singh, Singh, Kumari, Chopra, Sharma, Nepovimova, Valis, Kuca and Emran.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10603 - Genetics and heredity (medical genetics to be 3)
Result continuities
Project
<a href="/en/project/NV19-09-00578" target="_blank" >NV19-09-00578: AGING PREVENTION – Simultaneous modulation of ABAD and mTOR signaling pathway</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2022
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Frontiers in Genetics
ISSN
1664-8021
e-ISSN
1664-8021
Volume of the periodical
13
Issue of the periodical within the volume
October
Country of publishing house
CH - SWITZERLAND
Number of pages
15
Pages from-to
"Article number: 1022739"
UT code for WoS article
000885053400001
EID of the result in the Scopus database
2-s2.0-85142077245