Mycotoxins and cellular senescence: the impact of oxidative stress, hypoxia, and immunosuppression

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62690094%3A18470%2F23%3A50019656" target="_blank" >RIV/62690094:18470/23:50019656 - isvavai.cz</a>

Result on the web

<a href="https://link.springer.com/article/10.1007/s00204-022-03423-x?utm_source=getftr&utm_medium=getftr&utm_campaign=getftr_pilot" target="_blank" >https://link.springer.com/article/10.1007/s00204-022-03423-x?utm_source=getftr&utm_medium=getftr&utm_campaign=getftr_pilot</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s00204-022-03423-x" target="_blank" >10.1007/s00204-022-03423-x</a>

Result language

angličtina

Original language name

Mycotoxins and cellular senescence: the impact of oxidative stress, hypoxia, and immunosuppression

Original language description

Mycotoxins induce oxidative stress, hypoxia, and cause immunosuppressive effects. Moreover, emerging evidence show that mycotoxins have a potential of inducing cellular senescence, which are involved in their immunomodulatory effects. Mycotoxins upregulate the expression of senescence markers γ-H2AX, senescence-associated β-galactosidase, p53, p16, and senescence-associated secretory phenotype (SASP) inflammatory factors. Moreover, mycotoxins cause senescence-associated cell cycle arrest by diminishing cyclin D1 and Cdk4 pathways, as well as increasing the expression of p53, p21, and CDK6. Mycotoxins may induce cellular senescence by activating reactive oxygen species (ROS)-induced oxidative stress. In addition, hypoxia acts as a double-edged sword on cell senescence; it could both act as the stress-induced senescence and also hinder the onset of cellular senescence. The SASP inflammatory factors have the ability to induce an immunosuppressive environment, while mycotoxins directly cause immunosuppression. Therefore, there is a potential relationship between mycotoxins and cellular senescence that synergistically cause immunosuppression. However, most of the current studies have involved the effect of mycotoxins on cell cycle arrest, but only limited in-depth research has been carried out to link the occurrence of this condition (cell cycle arrest) with cellular senescence. © 2022, The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30108 - Toxicology

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2023

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Archives of toxicology

ISSN

0340-5761

e-ISSN

1432-0738

Volume of the periodical

97

Issue of the periodical within the volume

2

Country of publishing house

DE - GERMANY

Number of pages

12

Pages from-to

393-404

UT code for WoS article

000888695100001

EID of the result in the Scopus database

2-s2.0-85142544475