Combining Selective Laser Sintering and Fused Deposition Modeling of Pharmaceutical Polymers: A Novel Approach to Prepare Intestine-Targeted Tablets
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62690094%3A18470%2F25%3A50022467" target="_blank" >RIV/62690094:18470/25:50022467 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11160/25:10505084 RIV/00216275:25310/25:39923091
Result on the web
<a href="https://onlinelibrary.wiley.com/doi/10.1002/mame.202400460" target="_blank" >https://onlinelibrary.wiley.com/doi/10.1002/mame.202400460</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/mame.202400460" target="_blank" >10.1002/mame.202400460</a>
Alternative languages
Result language
angličtina
Original language name
Combining Selective Laser Sintering and Fused Deposition Modeling of Pharmaceutical Polymers: A Novel Approach to Prepare Intestine-Targeted Tablets
Original language description
This study introduces a novel approach to prepare an intestine-targeting transport system with a controlled drug release profile, combining two 3D printing techniques: selective laser sintering (SLS) and fused deposition modeling (FDM). Material evaluations indicate that a mixture of Kollidon (R) VA64 with 20% of Kollicoat (R) IR and 0.2% of Aeroperl (R) has the best flow behavior and exhibits optimal printability at a laser speed of 90 mm s-1. The formulation is subsequently drug-loaded and the printed cores are coated using the FDM technique. The core serves as a drug carrier and the FDM coating shell, consisting of 95% HPMC and 5% pectin, provides modified drug release and enhanced mechanical resistance of the tablet. The coating exhibits acid-resistant properties, with no drug release in the pH of 1.2 during the first 120 min of dissolution testing. In the pH of 6.8, the release profile shows zero-order kinetics with a constant release rate of 0.249% min-1 (in the time interval from 255 to 480 min). At the time point of 720 min, 92% of the drug is released. Dissolution testing thus demonstrates delayed and prolonged drug release. Combining both 3D printing methods shows great potential for personalized treatment of intestinal inflammatory diseases.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10404 - Polymer science
Result continuities
Project
—
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
MACROMOLECULAR MATERIALS AND ENGINEERING
ISSN
1438-7492
e-ISSN
1439-2054
Volume of the periodical
310
Issue of the periodical within the volume
6
Country of publishing house
DE - GERMANY
Number of pages
13
Pages from-to
"Article number: 2400460"
UT code for WoS article
001426031600001
EID of the result in the Scopus database
2-s2.0-85219699128