Interplay between circadian rhythms and epigenetics in neural stem cells and Alzheimer's disease
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62690094%3A18470%2F25%3A50022592" target="_blank" >RIV/62690094:18470/25:50022592 - isvavai.cz</a>
Result on the web
<a href="https://www.sciencedirect.com/science/article/pii/S0301008225000991?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0301008225000991?via%3Dihub</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.pneurobio.2025.102808" target="_blank" >10.1016/j.pneurobio.2025.102808</a>
Alternative languages
Result language
angličtina
Original language name
Interplay between circadian rhythms and epigenetics in neural stem cells and Alzheimer's disease
Original language description
The circadian clock, as a molecular timekeeper, influences most behavioural and physiological processes. Numerous symptoms associated with neurodegenerative diseases, such as sleep disorders, anxiety, and mood alteration, are linked to circadian clock dysregulation. Dysregulation of the circadian system is increasingly implicated in the onset and progression of Alzheimer's disease, and emerging evidence highlights a bidirectional relationship between Alzheimer's disease and circadian clock disruption. A crucial point is that the circadian clock regulates adult neurogenesis, a process that is significantly impaired in Alzheimer's disease. Recent advancements suggest that the dynamic epigenetic mechanisms—including DNA and histone modifications as well as regulation by non-coding RNA—act as a critical regulation for circadian rhythms and neurogenesis. Therefore, research on circadian disruption and, particularly, focus on harmonising the circadian clock with neurogenesis in neurodegenerative diseases may also speed up the creation of innovative, circadian-based treatments to counteract the progress of neurological disorders from a new perspective. In this review, we explore potential epigenetic mechanisms linking the circadian system to neurodegenerative diseases, with a focus on Alzheimer's Disease.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30103 - Neurosciences (including psychophysiology)
Result continuities
Project
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Continuities
R - Projekt Ramcoveho programu EK
Others
Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Progress in Neurobiology
ISSN
0301-0082
e-ISSN
1873-5118
Volume of the periodical
252
Issue of the periodical within the volume
September
Country of publishing house
GB - UNITED KINGDOM
Number of pages
13
Pages from-to
"Article Number: 102808"
UT code for WoS article
001575201900003
EID of the result in the Scopus database
2-s2.0-105013136482