Dissolution of fluconazole from 3D-printed prolonged-release tablets: a quantitative evaluation
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62690094%3A18470%2F25%3A50023035" target="_blank" >RIV/62690094:18470/25:50023035 - isvavai.cz</a>
Result on the web
<a href="https://www.sciencedirect.com/science/article/pii/S0378517325010282?pes=vor&utm_source=clarivate&getft_integrator=clarivate" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0378517325010282?pes=vor&utm_source=clarivate&getft_integrator=clarivate</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.ijpharm.2025.126191" target="_blank" >10.1016/j.ijpharm.2025.126191</a>
Alternative languages
Result language
angličtina
Original language name
Dissolution of fluconazole from 3D-printed prolonged-release tablets: a quantitative evaluation
Original language description
Among the many applications of additive technologies, their use in drug formulation holds a particularly important place. Numerous studies have been conducted on using various 3D printing techniques to produce both immediate- and modified-release dosage forms. However, the drug release mechanism may vary depending on the manufacturing method and formulation composition. This work aimed to analyze the influence of the 3D printing method used on the mechanism of fluconazole release from prolonged-release tablets. We conducted an analysis of tablets containing 50 mg of fluconazole, produced using two 3D printing techniques: Fused Deposition Modeling (FDM) and Liquid Crystal Display (LCD, classified as one of the Vat Photopolymerization (VPP) methods). Because FDM and VPP techniques build objects in fundamentally different ways, a unique set of excipients was used for each of these methods. For the FDMprinted tablets, poly(vinyl alcohol) was used to control drug release and as the filament-forming polymer. The tablet matrix produced using the VPP method was based on the cross-linked polyethylene glycol diacrylate. Both formulations were characterized by prolonged release of API. Employing surface dissolution imaging and kinetic models, we demonstrated that in the case of FDM-printed tablets, the API release is mainly regulated by the relaxation and gradual decay of the water-soluble polymer. In contrast, the relaxation of the water-insoluble matrix of VPP tablets was negligible. Although the diameter of the VPP tablets increased slightly during the dissolution study, the API release was primarily controlled by the diffusion of fluconazole through the crosslinked polymer.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30104 - Pharmacology and pharmacy
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
International Journal of Pharmaceutics
ISSN
0378-5173
e-ISSN
1873-3476
Volume of the periodical
685
Issue of the periodical within the volume
November
Country of publishing house
NL - THE KINGDOM OF THE NETHERLANDS
Number of pages
11
Pages from-to
"Article Number: 126191"
UT code for WoS article
001583688200005
EID of the result in the Scopus database
2-s2.0-105020835431