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Mutation Analysis Ion Channel Genes Ventricular Fibrillation Survivors with Coronary Artery Disease

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F65269705%3A_____%2F11%3A%230001316" target="_blank" >RIV/65269705:_____/11:#0001316 - isvavai.cz</a>

  • Alternative codes found

    RIV/00216224:14110/11:00080233

  • Result on the web

    <a href="http://dx.doi.org/10.1111/j.1540-8159.2011.03045.x" target="_blank" >http://dx.doi.org/10.1111/j.1540-8159.2011.03045.x</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1111/j.1540-8159.2011.03045.x" target="_blank" >10.1111/j.1540-8159.2011.03045.x</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Mutation Analysis Ion Channel Genes Ventricular Fibrillation Survivors with Coronary Artery Disease

  • Original language description

    Background: Observations from population-based studies demonstrated a strong genetic component of sudden cardiac death. The aim of this study was to test the hypothesis that ion channel genes mutations are more common in ventricular fibrillation (VF) survivors with coronary artery disease (CAD) compared to controls. Methods: The entire coding sequence of KCNQ1, KCNH2, SCN5A, KCNE1, and KCNE2 genes was analyzed in 45 (five females) CAD individuals?survivors of documented VF and in 90 matched healthy controls. In another control group of 141 matched patients with CAD without malignant arrhythmias, the exons containing rare coding variants found in the VF survivors were sequenced. Results: The carrier frequency of all the rare sequence variants was significantly higher in the VF survivors (8/45, 17.8%) than in CAD controls (3/141, 2.2%, P = 0.001). In VF survivors, four coding variants in eight individuals were found. Three in KCNH2 gene: R148W and GAG186del are novel; P347S was previousl

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    FA - Cardiovascular diseases including cardio-surgery

  • OECD FORD branch

Result continuities

  • Project

    <a href="/en/project/NR9340" target="_blank" >NR9340: Occurence of myocardial ion channel genes polymorphisms in relationship to sudden cardiac death in patients with structural heart disease</a><br>

  • Continuities

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Others

  • Publication year

    2011

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Pacing and Clinical Electrophysiology

  • ISSN

    0147-8389

  • e-ISSN

  • Volume of the periodical

    34

  • Issue of the periodical within the volume

    6

  • Country of publishing house

    US - UNITED STATES

  • Number of pages

    8

  • Pages from-to

    742-749

  • UT code for WoS article

    000291395000018

  • EID of the result in the Scopus database