Mutation Analysis Ion Channel Genes Ventricular Fibrillation Survivors with Coronary Artery Disease
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F65269705%3A_____%2F11%3A%230001316" target="_blank" >RIV/65269705:_____/11:#0001316 - isvavai.cz</a>
Alternative codes found
RIV/00216224:14110/11:00080233
Result on the web
<a href="http://dx.doi.org/10.1111/j.1540-8159.2011.03045.x" target="_blank" >http://dx.doi.org/10.1111/j.1540-8159.2011.03045.x</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1111/j.1540-8159.2011.03045.x" target="_blank" >10.1111/j.1540-8159.2011.03045.x</a>
Alternative languages
Result language
angličtina
Original language name
Mutation Analysis Ion Channel Genes Ventricular Fibrillation Survivors with Coronary Artery Disease
Original language description
Background: Observations from population-based studies demonstrated a strong genetic component of sudden cardiac death. The aim of this study was to test the hypothesis that ion channel genes mutations are more common in ventricular fibrillation (VF) survivors with coronary artery disease (CAD) compared to controls. Methods: The entire coding sequence of KCNQ1, KCNH2, SCN5A, KCNE1, and KCNE2 genes was analyzed in 45 (five females) CAD individuals?survivors of documented VF and in 90 matched healthy controls. In another control group of 141 matched patients with CAD without malignant arrhythmias, the exons containing rare coding variants found in the VF survivors were sequenced. Results: The carrier frequency of all the rare sequence variants was significantly higher in the VF survivors (8/45, 17.8%) than in CAD controls (3/141, 2.2%, P = 0.001). In VF survivors, four coding variants in eight individuals were found. Three in KCNH2 gene: R148W and GAG186del are novel; P347S was previousl
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FA - Cardiovascular diseases including cardio-surgery
OECD FORD branch
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Result continuities
Project
<a href="/en/project/NR9340" target="_blank" >NR9340: Occurence of myocardial ion channel genes polymorphisms in relationship to sudden cardiac death in patients with structural heart disease</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2011
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Pacing and Clinical Electrophysiology
ISSN
0147-8389
e-ISSN
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Volume of the periodical
34
Issue of the periodical within the volume
6
Country of publishing house
US - UNITED STATES
Number of pages
8
Pages from-to
742-749
UT code for WoS article
000291395000018
EID of the result in the Scopus database
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