Successful Anakinra Therapy in 2 Patients with Schnitzler Syndrome

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F65269705%3A_____%2F11%3A%230001541" target="_blank" >RIV/65269705:_____/11:#0001541 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.1159/000327816" target="_blank" >http://dx.doi.org/10.1159/000327816</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1159/000327816" target="_blank" >10.1159/000327816</a>

Result language

angličtina

Original language name

Successful Anakinra Therapy in 2 Patients with Schnitzler Syndrome

Original language description

Background: Schnitzler syndrome is a rare idiopathic disease characterized by chronic urticaria, presence of monoclonal IgM immunoglobulin, signs of inflammation and further symptoms. Often unrecognized, it may evolve into a lymphoproliferative disorder.Case Report: Two male patients presented pruritic and nonpruritic urticarias at the age of 45 and 43 years, respectively. Based on further symptoms (fever or subfebrile temperatures, bone and joint pains), laboratory tests (monoclonal IgM kappa, leukocytosis, elevated ESR and CRP) and radiological findings (osteolytic-osteosclerotic and hyperostotic skeletal changes), they were subsequently diagnosed with Schnitzler syndrome. Follow-up times were 15 years and 1 year, respectively. We monitored diseaseactivity in the second patient, finding a correlation with CRP, ESR and interleukin IL-6 and IL-18 serum levels. As regards therapy, we used several medications (antihistamines, bisphosphonates, corticoids, 2-chlorodeoxyadenosine, interfe

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FD - Oncology and haematology

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2011

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Onkologie

ISSN

0378-584X

e-ISSN

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Volume of the periodical

34

Issue of the periodical within the volume

5

Country of publishing house

CH - SWITZERLAND

Number of pages

4

Pages from-to

265-268

UT code for WoS article

000290560200009

EID of the result in the Scopus database

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