Two frequent polymorphisms of angiotensinogen and their association with multiple sclerosis progression rate

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F65269705%3A_____%2F11%3A%230001542" target="_blank" >RIV/65269705:_____/11:#0001542 - isvavai.cz</a>
Alternative codes found
RIV/00216224:14740/11:00054011
Result on the web
<a href="http://dx.doi.org/10.1016/j.jns.2011.01.020" target="_blank" >http://dx.doi.org/10.1016/j.jns.2011.01.020</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.jns.2011.01.020" target="_blank" >10.1016/j.jns.2011.01.020</a>

Result language
angličtina
Original language name
Two frequent polymorphisms of angiotensinogen and their association with multiple sclerosis progression rate
Original language description
A total of 195 patients with multiple sclerosis (MS) and 126 controls were investigated for angiotensinogen/(-6)A/G, M235T/and angiotensin converting enzyme I/D gene polymorphisms to test their association with MS susceptibility and/or disease progression using Global Multiple Sclerosis Severity Score (MSSS). We demonstrated a significant association of M235T polymorphism with MSSS. The MM homozygotes had the lowest (3.8), heterozygotes MT higher (5.2) and homozygotes TT the highest (5.4) mean MSSS values (P = 0.02). For polymorphisms (-6)A/G of ATG, only a trend was observed (P = 0.06), where the homozygotes GG carried lower MSSS values than heterozygotes and homozygotes AA. No significant association with susceptibility was observed. For ACE I/D polymorphism, neither significant differences in the genotype-phenotype study nor in the case-control study were observed.
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FH - Neurology, neuro-surgery, nuero-sciences
OECD FORD branch
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Publication year
2011
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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