Apoptosis inhibitor 5 (API-5; AAC-11; FIF) is upregulated in human carcinomas in vivo
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F65269705%3A_____%2F12%3A%230001836" target="_blank" >RIV/65269705:_____/12:#0001836 - isvavai.cz</a>
Alternative codes found
RIV/68081707:_____/12:00379296 RIV/00216224:14110/12:00065918
Result on the web
<a href="http://dx.doi.org/10.3892/ol.2012.593" target="_blank" >http://dx.doi.org/10.3892/ol.2012.593</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3892/ol.2012.593" target="_blank" >10.3892/ol.2012.593</a>
Alternative languages
Result language
angličtina
Original language name
Apoptosis inhibitor 5 (API-5; AAC-11; FIF) is upregulated in human carcinomas in vivo
Original language description
Apoptosis inhibitor 5 (API-5) is a 55 kDa nuclear protein with potent anti-apoptotic signaling in tumor cells in vitro. In this study, we analyzed the expression of the API-5 protein in vivo in a broad spectrum of human carcinomas, including those of thecolon, lung, liver, kidney, pancreas, stomach and esophagus using tumor tissues obtained during tumor resection. The results showed significant upregulation of API-5 expression in biopsies of lung (23%, n=13) and colorectal tumors (33%, n=27) in comparison with biopsies from the adjacent normal tissue. Colon cancer biopsies were used to study the cell populations with an upregulated level of expression of API-5 more closely. Using a magnetic bead based selection for the epithelial cell marker EpCAM, wepurified epithelial cells from the tumor and control tissues and analyzed these cells for API-5 expression by western immunoblotting. We observed that EpCAM-positive tumor cells expressed API-5 in all three colorectal cancer cases tested
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FD - Oncology and haematology
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
V - Vyzkumna aktivita podporovana z jinych verejnych zdroju
Others
Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Oncology letters
ISSN
1792-1074
e-ISSN
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Volume of the periodical
3
Issue of the periodical within the volume
4
Country of publishing house
GR - GREECE
Number of pages
4
Pages from-to
913-916
UT code for WoS article
000301307600033
EID of the result in the Scopus database
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