Per3 VNTR polymorphism and chronic heart failure
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F65269705%3A_____%2F12%3A%230001853" target="_blank" >RIV/65269705:_____/12:#0001853 - isvavai.cz</a>
Alternative codes found
RIV/65269705:_____/14:00061265 RIV/00159816:_____/14:00061265 RIV/00216224:14110/14:00080123
Result on the web
<a href="http://dx.doi.org/10.5507/bp.2012.069" target="_blank" >http://dx.doi.org/10.5507/bp.2012.069</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.5507/bp.2012.069" target="_blank" >10.5507/bp.2012.069</a>
Alternative languages
Result language
angličtina
Original language name
Per3 VNTR polymorphism and chronic heart failure
Original language description
Aims: The aim of this study was to investigate the relationship between gene Period3 (Per3) variable number tandem repeat (VNTR) polymorphism and chronic heart failure (CHF). Methods: The study subjects (372 patients of Caucasian origin with CHF and 332healthy controls) were genotyped for Per3 VNTR polymorphism using an allele-specific PCR. Results: No significant differences in genotype or Per3 VNTR allele frequencies were found between CHF cases and controls (Pg=0.30, Pa=0.52). No significant differences were uncovered either between CHF cases according to etiology (DCMP vs. IHD; Pg=0.87, Pa=0.91). In the multivariate regression modeling, no predictive function of VNTR Per3 polymorphism on ejection fraction or NYHA class, hyperlipidaemia or type IIdiabetes risk was found. Conclusion: Per3 VNTR polymorphism is not a major risk factor for chronic heart failure or a factor modulating the severity of the CHF in this population.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FA - Cardiovascular diseases including cardio-surgery
OECD FORD branch
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Result continuities
Project
<a href="/en/project/NS10206" target="_blank" >NS10206: Association of polymorphisms in genes for matrix metalloproteinases, their inhibitors, ACE and ACE2 with central pulse pressure in cardiovascular patients</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Biomedical Papers of the Medical Faculty of Palacky University in Olomouc
ISSN
1213-8118
e-ISSN
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Volume of the periodical
156
Issue of the periodical within the volume
10
Country of publishing house
CZ - CZECH REPUBLIC
Number of pages
4
Pages from-to
1-4
UT code for WoS article
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EID of the result in the Scopus database
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