MicroRNA signature associated with poor outcome of glioblastoma patients
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F65269705%3A_____%2F14%3A00062729" target="_blank" >RIV/65269705:_____/14:00062729 - isvavai.cz</a>
Alternative codes found
RIV/00216224:14110/14:00080178
Result on the web
<a href="http://neuro-oncology.oxfordjournals.org/content/16/suppl_5/v126.2" target="_blank" >http://neuro-oncology.oxfordjournals.org/content/16/suppl_5/v126.2</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1093/neuonc/nou262.6" target="_blank" >10.1093/neuonc/nou262.6</a>
Alternative languages
Result language
angličtina
Original language name
MicroRNA signature associated with poor outcome of glioblastoma patients
Original language description
BACKGROUND: It is very important to find new biomarkers which can predict clinical outcomes of glioblastoma (GBM) and help in treatment decissions. MicroRNAs (miRNAs) are small, non-coding RNAs that function as post-transcriptional regulators of gene expression and play key role in pathogenesis of wide range of cancer. Aim of our study is to identify miRNA signature associated with the more aggressive phenotype of GBMs, which will enable sensitive prediction of clinical outcome in GBM patients. METHODS:We determined the expression profile of 667 miRNAs in tumor tissues of 58 patients with primary GBM with completed concomitant chemoradiotherapy with temozolomide and 12 non-malignant brain tissues obtained from patients with drug-resistant anteromedialtemporal lobe epilepsy. Methylation status of MGMT promoter (methylation-specific HRM), isocitrate dehydrogenase (IDH1) status (immunohistochemistry) and co-deletion of 1p/19q (FISH) was also evaluated. RESULTS: We have confirmed frequen
Czech name
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Czech description
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Classification
Type
O - Miscellaneous
CEP classification
FH - Neurology, neuro-surgery, nuero-sciences
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů